Klapdor R
Acta Hepatogastroenterol (Stuttg). 1979 Feb;26(1):23-5.
In 15 patients (n = 6 without and n = 9 with liver diseases) we measured the plasma disappearance curves after single injections of C 14-glycocholate, calculated the distribution and excretion kinetics on the basis of a 2- and 3-compartmental model and compared the calculated values for the maximal C 14-accumulation within compartment 2 that should correspond to the liver in both compartmental models. The results demonstrate that only the 3-compartmental model reproduces the pathophysiological situation in the patients with liver injuries, namely a decrease of the maximal C 14-accumulation within the liver and an increased C 14-accumulation within the extrahepatoplasmatic compartment. The results therefore confirm our previous studies in healthy patients even for the patient with liver diseases.
在15名患者中（6名无肝脏疾病，9名有肝脏疾病），我们在单次注射C 14 - 甘氨胆酸盐后测量了血浆消失曲线，基于二室和三室模型计算了分布和排泄动力学，并比较了两个模型中应对应于肝脏的第二室中最大C 14积累的计算值。结果表明，只有三室模型能再现肝损伤患者的病理生理情况，即肝脏内最大C 14积累减少，肝外质腔室中C 14积累增加。因此，这些结果证实了我们之前对健康患者的研究，甚至对于患有肝脏疾病的患者也是如此。
