Linn W S, Shamoo D A, Venet T G, Spier C E, Valencia L M, Anzar U T, Hackney J D
Arch Environ Health. 1983 Sep-Oct;38(5):278-83. doi: 10.1080/00039896.1983.10544007.
Twenty-eight volunteers with chronic obstructive pulmonary disease were exposed to 0.0, 0.18, and 0.25 ppm ozone in purified air for 1-hr periods with light intermittent exercise, with exposure conditions presented in random order at 1-month intervals. No statistically significant changes attributable to ozone were found in forced expiratory performance or percent oxyhemoglobin (measured near the beginning and end of each exposure). No ozone-related changes in clinical status were found by interviews that included the time for 1 wk before to 1 wk after each exposure, except that a moderate increase in lower respiratory symptoms was reported by nonsmokers in 0.18 ppm exposures only. Thus, a slight decrement in hemoglobin saturation with ozone exposure (reported in two previous studies of chronic obstructive pulmonary disease subjects) may not be a common occurrence under typical ambient exposure conditions.
28名慢性阻塞性肺疾病志愿者在纯净空气中分别暴露于0.0、0.18和0.25 ppm的臭氧中，每次暴露1小时，并进行轻度间歇性运动，暴露条件以随机顺序每隔1个月呈现一次。在每次暴露开始和结束时测量的用力呼气性能或氧合血红蛋白百分比方面，未发现因臭氧导致的具有统计学意义的变化。通过访谈发现，在每次暴露前1周和暴露后1周的时间段内，未发现与臭氧相关的临床状态变化，但仅在0.18 ppm暴露组中，非吸烟者报告下呼吸道症状有中度增加。因此，在典型的环境暴露条件下，臭氧暴露导致血红蛋白饱和度略有下降（在之前两项针对慢性阻塞性肺疾病受试者的研究中有报道）可能并不常见。
