Linn W S, Fischer D A, Medway D A, Anzar U T, Spier C E, Valencia L M, Venet T G, Hackney J D
Am Rev Respir Dis. 1982 Jun;125(6):658-63. doi: 10.1164/arrd.1982.125.6.658.
Twenty-five volunteers with chronic obstructive pulmonary disease of mild to moderately severe degree underwent 1-h exposures to 0.12 ppm ozone (O2) in purified air with intermittent mild exercise. Their responses were assessed in terms of forced expiratory performance, ear oximetry, and reported symptoms. Control studied consisted of similar exposures to purified air alone. Control studies were separated from O2 exposures by 1 month, and the order was randomized. All studies took place in a controlled-environment chamber, and were preceded by approximately 1 h of rest in a purified-air environment. No significant disturbances in forced expiratory performance or symptoms attributable to O2 exposure were found. A slight but significant tendency to decreased arterial hemoglobin oxygen saturation (SaO2) during exercise in O2 was observed. The decrement in SaO2 with O2 relative to clean air (mean 1.3%) was near the limit of resolution of the ear oximeter test and was detected by signal averaging, thus its physiologic or clinical significance is uncertain.
25名患有轻度至中度严重程度慢性阻塞性肺疾病的志愿者在经过间歇性轻度运动的纯净空气中暴露于0.12 ppm臭氧（O₂）1小时。根据用力呼气性能、耳部血氧饱和度测定和报告的症状对他们的反应进行评估。对照研究包括仅暴露于纯净空气中。对照研究与O₂暴露相隔1个月，且顺序是随机的。所有研究均在可控环境舱内进行，并且在纯净空气环境中休息约1小时后进行。未发现因O₂暴露导致用力呼气性能或症状出现明显干扰。观察到在O₂环境中运动期间动脉血红蛋白氧饱和度（SaO₂）有轻微但显著的下降趋势。与洁净空气相比，O₂导致的SaO₂下降（平均1.3%）接近耳部血氧饱和度测定测试的分辨率极限，并且是通过信号平均检测到的，因此其生理或临床意义尚不确定。
