Cunningham V J, Tucker S P, Bailey E
Arch Toxicol. 1983 Oct;54(2):157-62. doi: 10.1007/BF01261384.
The fate of oleylanilide, administered as a single intragastric dose in rape oil, has been studied in Porton Wistar rats. Following a dose of oleyl[U-14C]anilide approximately 60% of the label was recovered in the faeces over a 3 day period, and identified principally as unchanged anilide. Most of the remainder of the dose was recovered in urine as hydrophilic metabolites. p-hydroxyacetanilide, which is a major metabolite of aniline in the rat was identified in the hydrolysed samples of urine from anilide treated rats. Following administration of [9,10(n)-3H]oleyl[U-14C]-anilide to rats which had been fitted with a cannula in the thoracic lymph duct the [3H] label which was absorbed was recovered principally in triglycerides showing that extensive hydrolysis of the anilide occurs prior to or during uptake from the gut. Oleylanilide was identified in lymph by gas chromatography but amounted to less than 6% of the dose.
已在波顿威斯塔大鼠中研究了以单剂量经胃内给予菜籽油中的油酰苯胺的命运。给予一剂油酰基[U-¹⁴C]苯胺后，在3天内约60%的放射性标记物在粪便中回收，主要鉴定为未变化的苯胺。该剂量的其余大部分以亲水性代谢产物的形式在尿液中回收。对羟基乙酰苯胺是大鼠体内苯胺的主要代谢产物，在经苯胺处理的大鼠尿液水解样品中被鉴定出来。向已在胸导管插入套管的大鼠给予[9,10(n)-³H]油酰基[U-¹⁴C] -苯胺后，吸收的[³H]标记物主要在甘油三酯中回收，这表明苯胺在从肠道吸收之前或期间发生了广泛水解。通过气相色谱法在淋巴中鉴定出油酰苯胺，但含量不到剂量的6%。
