Nelson J D, Havener V R, Cameron J D
Arch Ophthalmol. 1983 Dec;101(12):1869-72. doi: 10.1001/archopht.1983.01040020871007.
Cellulose acetate impressions of the ocular surface were obtained for normal eyes, eyes with blepharoconjunctivitis, eyes with keratoconjunctivitis sicca, and eyes with primary ocular surface disease. Normal eyes and eyes with blepharoconjunctivitis had morphologically normal epithelium and goblet cells on the bulbar and palpebral ocular surfaces. Eyes with primary ocular surface disease had abnormal ocular surface impressions (decreased, abnormal, or absent goblet cells with abnormal epithelial cells) on both the bulbar and palpebral ocular surfaces. Conversely, eyes with keratoconjunctivitis sicca had substantial abnormalities of the epithelium and goblet cells only on the bulbar ocular surface, suggesting an environmental role in this disease process.
获取了正常眼睛、患有睑结膜炎的眼睛、患有干眼症的眼睛以及患有原发性眼表疾病的眼睛的眼表醋酸纤维素印模。正常眼睛和患有睑结膜炎的眼睛在球结膜和睑结膜眼表的上皮和杯状细胞形态正常。患有原发性眼表疾病的眼睛在球结膜和睑结膜眼表均有异常的眼表印模（杯状细胞减少、异常或缺失，伴有异常上皮细胞）。相反，患有干眼症的眼睛仅在球结膜眼表存在上皮和杯状细胞的实质性异常，提示环境因素在该疾病过程中起作用。
