Price P, Turner K J
Aust J Exp Biol Med Sci. 1983 Aug;61 (Pt 4):371-82. doi: 10.1038/icb.1983.35.
The characteristics of primary Nematospiroides dubius, mouse-adapted Nippostrongylus brasiliensis and Trichuris muris infections in C57BL mice and their broad effects on lymphoid tissue and reticuloendothelial function have been compared in an attempt to identify correlations between the effects of the parasites and common features of their life cycles. All three parasites increased the size of the spleen and mesenteric node, roughly in proportion to the intestinal worm burden. N. brasiliensis and T. muris caused thymic atrophy, which was not evident with N. dubius even when it was administered intravenously (i.v.) to establish a tissue migration phase. N. brasiliensis accelerated the clearance of I125-labelled polyvinyl pyrrolidone (I125-PVP) from the circulation by increasing uptake by the liver and lungs. N. dubius caused similar increases when given i.v., suggesting that macrophages in these organs are activated by migrating larvae, but did not affect the levels of I125-PVP in circulation. An established intestinal N. dubius infection increased the levels in circulation and in peritoneal cells.
在C57BL小鼠中，已比较了杜氏新圆线虫、适应小鼠的巴西日圆线虫和鼠鞭虫原发性感染的特征，以及它们对淋巴组织和网状内皮系统功能的广泛影响，以试图确定寄生虫的影响与其生命周期共同特征之间的相关性。所有这三种寄生虫都会使脾脏和肠系膜淋巴结增大，大致与肠道蠕虫负荷成比例。巴西日圆线虫和鼠鞭虫会导致胸腺萎缩，即使静脉注射杜氏新圆线虫以建立组织迁移阶段，胸腺萎缩也不明显。巴西日圆线虫通过增加肝脏和肺部的摄取，加速了循环中125I标记的聚乙烯吡咯烷酮（125I-PVP）的清除。静脉注射杜氏新圆线虫时也会引起类似的增加，这表明这些器官中的巨噬细胞被迁移的幼虫激活，但不影响循环中125I-PVP的水平。已建立的肠道杜氏新圆线虫感染会增加循环中和腹膜细胞中的水平。
