Price P, Turner K J
Aust J Exp Biol Med Sci. 1983 Aug;61 (Pt 4):397-409. doi: 10.1038/icb.1983.37.
Nematospiroides dubius, Nippostrongylus brasiliensis and Trichuris muris infections in C57BL mice increased background IgM titres to SRC but not to erythrocytes from other species. However, no cross-reaction between parasite extracts and SRC could be demonstrated and the enhancement was not evident in other strains of mice. There were no comparable rises in total IgM levels, but declining IgM responses to ovalbumin were boosted by N. dubius, so the rise was probably caused by selective expansion of activated clones of cells. N. dubius also increased responses to low doses of SRC given intraperitoneally (i.p.) a few days after infection, whilst optimal SRC doses induced normal responses. In contrast, N. brasiliensis and T. muris often depressed responses to SRC though the effect was variable and the timing of challenge was critical. Thus, whereas the enhancement of natural titres occurs in C57BL mice infected with any of the parasites tested here or in previous studies, the effects on responses to injected SRC depend on the species of parasite.
感染杜氏丝状线虫、巴西日圆线虫和鼠鞭虫的C57BL小鼠，其针对绵羊红细胞（SRC）的背景IgM滴度升高，但针对其他物种红细胞的IgM滴度未升高。然而，未证实寄生虫提取物与SRC之间存在交叉反应，且在其他品系小鼠中这种增强现象并不明显。总IgM水平没有类似升高，但杜氏丝状线虫增强了对卵清蛋白下降的IgM反应，因此这种升高可能是由活化细胞克隆的选择性扩增引起的。感染后几天，腹腔注射低剂量SRC时，杜氏丝状线虫也增强了小鼠的反应，而最佳SRC剂量则诱导正常反应。相比之下，巴西日圆线虫和鼠鞭虫常常抑制对SRC的反应，尽管效果不一，且攻击的时机至关重要。因此，虽然在此处或之前研究中感染任何测试寄生虫的C57BL小鼠都会出现自然滴度增强，但对注射SRC反应的影响则取决于寄生虫的种类。
