Maruyama Y, Nunokawa T, Koiwa Y, Isoyama S, Ikeda K, Ino-Oka E, Takishima T
Basic Res Cardiol. 1983 Sep-Oct;78(5):544-59. doi: 10.1007/BF01906465.
We investigated ventricular interaction by the use of six excised, perfused, canine hearts. In this preparation, we could change the filling pressure of the right and left ventricles independently, thereby breaking the normal series-pump arrangement. We found that mechanical ventricular interaction exists in diastole and in systole. Namely, not only decreased diastolic ventricular compliance, but also the reduced performance in either ventricle was found, when the opposite ventricular pressure was increased. Thus, when the opposite ventricular filling pressure increases, we suspect that systolic ventricular function of either ventricle will be depressed significantly by these two factors; i.e., the Frank-Starling effect due to decreased ventricular diastolic volume following decreased diastolic ventricular compliance, and the depressed systolic ventricular function. Clinically, these findings may be important in considering the mechanism of the occurrence of simultaneous reduced performance of both ventricles in cases when only one side of the ventricle is affected hemodynamically and its filling pressure is greatly increased in various pathological states such as heart failure.
我们使用六个切除并灌注的犬心脏来研究心室相互作用。在这个实验准备中，我们能够独立改变右心室和左心室的充盈压力，从而打破正常的串联泵结构。我们发现机械性心室相互作用在舒张期和收缩期均存在。也就是说，当对侧心室压力升高时，不仅舒张期心室顺应性降低，而且任一心室的功能也会下降。因此，当对侧心室充盈压力升高时，我们推测任一心室的收缩期心室功能会因这两个因素而显著降低；即舒张期心室顺应性降低导致舒张期心室容积减少所引起的Frank-Starling效应，以及收缩期心室功能降低。临床上，在考虑各种病理状态（如心力衰竭）下，当仅一侧心室血流动力学受到影响且其充盈压力大幅升高时，两心室同时出现功能降低的发生机制时，这些发现可能具有重要意义。
