Müller D, Greiling K, Greiling H, Klinger W
Biomed Biochim Acta. 1983;42(7-8):981-7.
The influence of T3 on some cytochrome P-450-dependent biotransformation reactions (ethylmorphine N-demethylation, ethoxycoumarin O-deethylation and ethoxyresorufin O-deethylation) was investigated in rats of different ages. After T3 administrations on 3 consecutive days to rats of different ages, on the 4th day ethylmorphine N-demethylation rate was diminished in all age groups. On the contrary, ethoxyresorufin and ethoxycoumarin O-deethylation rates were considerably enhanced, preferentially in 33-day-old animals. The P-450 concentration was increased to a smaller degree. After T3 treatment on the first 8 days of life long-term effects on ethylmorphine N-demethylation were observed. Low T3 doses accelerated this reaction in 33- and 60-day-old rats. Ethoxycoumarin O-deethylation was not influenced. T3 administrations cannot diminish age-differences in drug metabolism.
研究了T3对不同年龄大鼠某些细胞色素P-450依赖性生物转化反应（乙基吗啡N-脱甲基化、乙氧香豆素O-脱乙基化和乙氧试卤灵O-脱乙基化）的影响。在对不同年龄的大鼠连续3天给予T3后，第4天所有年龄组的乙基吗啡N-脱甲基化率均降低。相反，乙氧试卤灵和乙氧香豆素的O-脱乙基化率显著提高，在33日龄动物中尤为明显。P-450浓度升高程度较小。在出生后的前8天给予T3治疗后，观察到对乙基吗啡N-脱甲基化的长期影响。低剂量T3可加速33日龄和60日龄大鼠的这一反应。乙氧香豆素O-脱乙基化未受影响。给予T3不能消除药物代谢中的年龄差异。
