Margolis R K, Margolis R U
Biochem Biophys Res Commun. 1983 Nov 15;116(3):889-94. doi: 10.1016/s0006-291x(83)80225-3.
Large polysialosyl glycopeptides can be derived from the glycoproteins of both mature as well as early postnatal brain, although their concentration (in terms of sialic acid content) decreases by approximately 75 percent during the first month in rat brain. These glycopeptides were found to contain O-sulfate residues, and subcellular fractionation studies indicated that most of the glycoproteins having polysialosyl units are present in non-synaptic plasma membranes. Large polysialosyl glycopeptides can also be obtained from the membranes of PC12 pheochromocytoma cells, demonstrating that this type of structure is not unique to brain.
大型多唾液酸糖肽可源自成熟脑以及出生后早期脑的糖蛋白，尽管在大鼠脑中，其浓度（以唾液酸含量计）在出生后的第一个月内会下降约75%。这些糖肽被发现含有O-硫酸酯残基，亚细胞分级分离研究表明，大多数具有多唾液酸单元的糖蛋白存在于非突触质膜中。大型多唾液酸糖肽也可从PC12嗜铬细胞瘤细胞的膜中获得，这表明这种结构并非脑所特有。
