两种放射增敏铂化合物（顺式二氯双异丙胺反式二羟基铂IV（CHIP）和顺铂甲硝唑2Cl2（FLAP））在体外诱导CHO细胞中的姐妹染色单体交换。

Sister chromatid exchanges induced by two radiosensitizing platinum compounds (cis-dichloro-bis isopropylamine trans dihydroxy platinum IV (CHIP) and cis platinum metronidazole2Cl2(FLAP)) in CHO cells in vitro.

作者信息

Bocian E, Laverick M, Nias A H

出版信息

Br J Cancer. 1983 Dec;48(6):803-7. doi: 10.1038/bjc.1983.270.

DOI:10.1038/bjc.1983.270

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2011570/

Abstract

Sister chromatid exchange (SCE) induction by two radiosensitizing platinum compounds (cis-dichloro-bis isopropylamine trans dihydroxy platinum IV (CHIP) and cis-platinum metronidazole2 Cl2 (FLAP] was studied in CHO cells in vitro. Both drugs induced SCE in a dose dependent manner. CHIP was a much more potent inducer of SCE than FLAP and produced almost 4 times as many SCE as FLAP at equimolar concentrations and twice as many at equitoxic dosage. Induction of SCE by a component of the FLAP molecule--metronidazole--was also examined. It did not cause any increase of SCE frequency over the control level when applied at 10 times the highest concentration of FLAP which was used.

摘要

在体外培养的中国仓鼠卵巢（CHO）细胞中，研究了两种放射增敏铂化合物（顺式 - 二氯 - 双异丙胺反式二羟基铂IV（CHIP）和顺铂甲硝唑2 Cl2（FLAP））对姐妹染色单体交换（SCE）的诱导作用。两种药物均以剂量依赖性方式诱导SCE。CHIP诱导SCE的能力比FLAP强得多，在等摩尔浓度下产生的SCE几乎是FLAP的4倍，在等毒性剂量下是FLAP的两倍。还研究了FLAP分子的一个成分甲硝唑对SCE的诱导作用。当以FLAP使用的最高浓度的10倍应用时，它不会使SCE频率比对照水平有任何增加。

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本文引用的文献

1

Hypoxic-cell sensitizers and sister chromatid exchanges.

Br J Radiol. 1980 Apr;53(628):376-7. doi: 10.1259/0007-1285-53-628-376.

2

A method utilizing human lymphocytes with in vitro metabolic activation for assessing chemical mutagenicity by sister-chromatid exchange analysis.

Mutat Res. 1980 Feb;69(2):283-91. doi: 10.1016/0027-5107(80)90093-7.

3

Modification of mutation frequency in plateau phase Chinese hamster ovary cells exposed to gamma radiation during recovery from potentially lethal damage.

Int J Radiat Biol Relat Stud Phys Chem Med. 1982 Nov;42(5):501-8. doi: 10.1080/09553008214551441.

4

Hypoxic cell sensitization to radiation damage by a new radiosensitizer: cis-dichloro-bis(1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole-N3)platinum(II) (flap).

Br J Cancer. 1982 Nov;46(5):701-5. doi: 10.1038/bjc.1982.261.

5

The mode of action of cis dichloro-bis (isopropylamine) trans dihydroxy platinum IV (CHIP) studied by the analysis of chromosome aberration production.

Br J Cancer. 1983 Apr;47(4):503-9. doi: 10.1038/bjc.1983.80.

6

Comparison of the incidence of oncogenic transformation produced by X rays, misonidazole, and chemotherapy agents.

Radiology. 1982 Nov;145(2):521-3. doi: 10.1148/radiology.145.2.6182579.

7

Sister chromatid exchanges.

Adv Hum Genet. 1980;10:267-331. doi: 10.1007/978-1-4615-8288-5_4.

8

New Giemsa method for the differential staining of sister chromatids.

Nature. 1974 Sep 13;251(5471):156-8. doi: 10.1038/251156a0.

9

Post-replication repair of DNA in Chinese hamster cells treated with cis platinum (II) diamine dichloride. Enhancement of toxicity and chromosome damage by caffeine.

Mutat Res. 1975 Dec;33(2-3):279-84. doi: 10.1016/0027-5107(75)90203-1.

10

Sister chromatid exchanges--a sensitive assay of agents damaging human chromosomes.

Mutat Res. 1975 Nov;30(2):273-8.

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