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1
Sister chromatid exchanges induced by two radiosensitizing platinum compounds (cis-dichloro-bis isopropylamine trans dihydroxy platinum IV (CHIP) and cis platinum metronidazole2Cl2(FLAP)) in CHO cells in vitro.两种放射增敏铂化合物（顺式二氯双异丙胺反式二羟基铂IV（CHIP）和顺铂甲硝唑2Cl2（FLAP））在体外诱导CHO细胞中的姐妹染色单体交换。
Br J Cancer. 1983 Dec;48(6):803-7. doi: 10.1038/bjc.1983.270.
2
Comparison of 6-thioguanine-resistant mutation and sister chromatid exchanges in Chinese hamster V79 cells with forty chemical and physical agents.中国仓鼠V79细胞中6-硫鸟嘌呤抗性突变与姐妹染色单体交换对四十种化学和物理因子的比较
Cancer Res. 1984 Aug;44(8):3270-9.
3
Effects of five platinum complexes (cis-DDP, trans-DDP, CHIP IV, CBDCA, oxo-Pt) on the induction of sister chromatid exchanges (SCEs) and chromosomal aberrations in Vicia faba root-tip cells.五种铂配合物（顺铂、反铂、CHIP IV、卡铂、氧铂）对蚕豆根尖细胞姐妹染色单体交换（SCEs）和染色体畸变诱导的影响。
Folia Biol (Praha). 1990;36(3-4):173-80.
4
Failure to induce sister chromatid exchanges (SCE) with metronidazole.
Toxicol Lett. 1981 Aug;8(6):359-61. doi: 10.1016/0378-4274(81)90126-0.
5
Chromosomal aberrations, sister chromatid exchange (SCEs) and micronuclei induction with three platinum compounds (cis-DDP, CHIP, CBDCA) in V79 cells in vitro.
Neoplasma. 1984;31(6):655-9.
6
Cytotoxicity and sister chromatid exchanges induced in vitro by six anticancer drugs developed in the People's Republic of China.中华人民共和国研制的六种抗癌药物在体外诱导的细胞毒性和姐妹染色单体交换
J Natl Cancer Inst. 1983 Oct;71(4):841-7.
7
The mode of action of cis dichloro-bis (isopropylamine) trans dihydroxy platinum IV (CHIP) studied by the analysis of chromosome aberration production.通过分析染色体畸变产生来研究顺二氯双（异丙胺）反二羟基铂（IV）（CHIP）的作用方式。
Br J Cancer. 1983 Apr;47(4):503-9. doi: 10.1038/bjc.1983.80.
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[Analysis of sister chromatid exchanges in the 1st, 2d and 3d mitoses using 5-bromodeoxyuridine and 5-bromodeoxycytidine].[使用5-溴脱氧尿苷和5-溴脱氧胞苷对第1、2和3次有丝分裂中的姐妹染色单体交换进行分析]
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Effects of retinoids on plating efficiency, sister-chromatid exchange (SCE) and mitomycin-C-induced SCE in cultured Chinese hamster cells.
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10
Cell cycle phase sensitivity to cis-dichloro-bis (isopropylamine) trans-dihydroxy platinum (IV) (CHIP).
Cell Tissue Kinet. 1986 Jul;19(4):419-27. doi: 10.1111/j.1365-2184.1986.tb00739.x.

引用本文的文献

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Evaluation of trans-tetrachloro-1,2-diaminocyclohexane platinum (IV) in murine leukemia L1210 resistant and sensitive to cis-diamminedichloroplatinum (II).
Cancer Chemother Pharmacol. 1987;20(2):96-100. doi: 10.1007/BF00253961.

本文引用的文献

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Hypoxic-cell sensitizers and sister chromatid exchanges.
Br J Radiol. 1980 Apr;53(628):376-7. doi: 10.1259/0007-1285-53-628-376.
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A method utilizing human lymphocytes with in vitro metabolic activation for assessing chemical mutagenicity by sister-chromatid exchange analysis.
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Modification of mutation frequency in plateau phase Chinese hamster ovary cells exposed to gamma radiation during recovery from potentially lethal damage.
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Hypoxic cell sensitization to radiation damage by a new radiosensitizer: cis-dichloro-bis(1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole-N3)platinum(II) (flap).一种新型放射增敏剂对缺氧细胞辐射损伤的增敏作用：顺式二氯 - 双（1 - （2 - 羟乙基）- 2 - 甲基 - 5 - 硝基咪唑 - N3）铂（II）（弗拉普）
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The mode of action of cis dichloro-bis (isopropylamine) trans dihydroxy platinum IV (CHIP) studied by the analysis of chromosome aberration production.通过分析染色体畸变产生来研究顺二氯双（异丙胺）反二羟基铂（IV）（CHIP）的作用方式。
Br J Cancer. 1983 Apr;47(4):503-9. doi: 10.1038/bjc.1983.80.
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Sister chromatid exchanges.姐妹染色单体交换
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New Giemsa method for the differential staining of sister chromatids.用于姐妹染色单体鉴别染色的新吉姆萨方法。
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Post-replication repair of DNA in Chinese hamster cells treated with cis platinum (II) diamine dichloride. Enhancement of toxicity and chromosome damage by caffeine.
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Sister chromatid exchanges--a sensitive assay of agents damaging human chromosomes.姐妹染色单体交换——一种检测损伤人类染色体因子的灵敏方法。
Mutat Res. 1975 Nov;30(2):273-8.

两种放射增敏铂化合物（顺式二氯双异丙胺反式二羟基铂IV（CHIP）和顺铂甲硝唑2Cl2（FLAP））在体外诱导CHO细胞中的姐妹染色单体交换。

Sister chromatid exchanges induced by two radiosensitizing platinum compounds (cis-dichloro-bis isopropylamine trans dihydroxy platinum IV (CHIP) and cis platinum metronidazole2Cl2(FLAP)) in CHO cells in vitro.

作者信息

Bocian E, Laverick M, Nias A H

出版信息

Br J Cancer. 1983 Dec;48(6):803-7. doi: 10.1038/bjc.1983.270.

DOI:10.1038/bjc.1983.270
PMID:6652019
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2011570/
Abstract

Sister chromatid exchange (SCE) induction by two radiosensitizing platinum compounds (cis-dichloro-bis isopropylamine trans dihydroxy platinum IV (CHIP) and cis-platinum metronidazole2 Cl2 (FLAP] was studied in CHO cells in vitro. Both drugs induced SCE in a dose dependent manner. CHIP was a much more potent inducer of SCE than FLAP and produced almost 4 times as many SCE as FLAP at equimolar concentrations and twice as many at equitoxic dosage. Induction of SCE by a component of the FLAP molecule--metronidazole--was also examined. It did not cause any increase of SCE frequency over the control level when applied at 10 times the highest concentration of FLAP which was used.

摘要

在体外培养的中国仓鼠卵巢（CHO）细胞中，研究了两种放射增敏铂化合物（顺式 - 二氯 - 双异丙胺反式二羟基铂IV（CHIP）和顺铂甲硝唑2 Cl2（FLAP））对姐妹染色单体交换（SCE）的诱导作用。两种药物均以剂量依赖性方式诱导SCE。CHIP诱导SCE的能力比FLAP强得多，在等摩尔浓度下产生的SCE几乎是FLAP的4倍，在等毒性剂量下是FLAP的两倍。还研究了FLAP分子的一个成分甲硝唑对SCE的诱导作用。当以FLAP使用的最高浓度的10倍应用时，它不会使SCE频率比对照水平有任何增加。