通过分析染色体畸变产生来研究顺二氯双（异丙胺）反二羟基铂（IV）（CHIP）的作用方式。
The mode of action of cis dichloro-bis (isopropylamine) trans dihydroxy platinum IV (CHIP) studied by the analysis of chromosome aberration production.
作者信息
Bocian E, Laverick M, Nias A H
出版信息
Br J Cancer. 1983 Apr;47(4):503-9. doi: 10.1038/bjc.1983.80.
Abstract
The induction of chromosome damage by the Platinum complex CHIP in Chinese hamster ovary (CHO) cells has been studied, together with the relationship between cell survival and aberration frequency. The type and frequency of chromosome aberrations observed in asynchronous and G1 phase treated cells indicated a similar mode of action to that of bifunctional alkylating agents. A log-linear relationship was observed between the frequency of chromatid aberrations (excluding gaps) and the level of survival after CHIP treatment, with approximately one aberration per cell corresponding to 37% survival.
摘要
研究了铂配合物CHIP对中国仓鼠卵巢（CHO）细胞染色体损伤的诱导作用，以及细胞存活与畸变频率之间的关系。在异步处理和G1期处理的细胞中观察到的染色体畸变类型和频率表明，其作用模式与双功能烷化剂相似。CHIP处理后，染色单体畸变（不包括裂隙）频率与存活水平之间呈对数线性关系，每细胞约一个畸变对应37%的存活率。
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