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1
The mode of action of cis dichloro-bis (isopropylamine) trans dihydroxy platinum IV (CHIP) studied by the analysis of chromosome aberration production.通过分析染色体畸变产生来研究顺二氯双（异丙胺）反二羟基铂（IV）（CHIP）的作用方式。
Br J Cancer. 1983 Apr;47(4):503-9. doi: 10.1038/bjc.1983.80.
2
Cell cycle phase sensitivity to cis-dichloro-bis (isopropylamine) trans-dihydroxy platinum (IV) (CHIP).
Cell Tissue Kinet. 1986 Jul;19(4):419-27. doi: 10.1111/j.1365-2184.1986.tb00739.x.
3
The radiomimetic properties of a platinum drug.
Br J Radiol. 1985 Jan;58(685):51-62. doi: 10.1259/0007-1285-58-685-51.
4
An in vitro study comparing the cytotoxicity of three platinum complexes with regard to the effect of thiol depletion.一项关于三种铂配合物细胞毒性的体外研究，比较其在巯基耗竭效应方面的情况。
Br J Cancer. 1988 Jun;57(6):548-52. doi: 10.1038/bjc.1988.126.
5
Sister chromatid exchanges induced by two radiosensitizing platinum compounds (cis-dichloro-bis isopropylamine trans dihydroxy platinum IV (CHIP) and cis platinum metronidazole2Cl2(FLAP)) in CHO cells in vitro.两种放射增敏铂化合物（顺式二氯双异丙胺反式二羟基铂IV（CHIP）和顺铂甲硝唑2Cl2（FLAP））在体外诱导CHO细胞中的姐妹染色单体交换。
Br J Cancer. 1983 Dec;48(6):803-7. doi: 10.1038/bjc.1983.270.
6
The mechanism of action of cis-dichloro-bis (isopropylamine) trans dihydroxyplatinum IV (CHIP) on Chinese hamster and C3H mouse tumor cells and its interaction with X-irradiation.顺二氯双（异丙胺）反二羟基铂（IV）（CHIP）对中国仓鼠和C3H小鼠肿瘤细胞的作用机制及其与X射线照射的相互作用。
Int J Radiat Oncol Biol Phys. 1979 Aug;5(8):1341-4. doi: 10.1016/0360-3016(79)90666-7.
7
Antimitotic and cytotoxic activity of cis-dichlorobis-(cyclohexylamine)platinum(II) on Chinese hamster ovary cells.
Chem Biol Interact. 1981 May;35(2):189-97. doi: 10.1016/0009-2797(81)90142-3.
8
Isobologram analysis of the combined effects of anti-tumour platinum complexes and ionizing radiation on mammalian cells.抗肿瘤铂配合物与电离辐射对哺乳动物细胞联合作用的等效线图分析
Br J Cancer. 1980 Aug;42(2):292-6. doi: 10.1038/bjc.1980.229.
9
Hypoxic cell sensitization to radiation damage by a new radiosensitizer: cis-dichloro-bis(1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole-N3)platinum(II) (flap).一种新型放射增敏剂对缺氧细胞辐射损伤的增敏作用：顺式二氯 - 双（1 - （2 - 羟乙基）- 2 - 甲基 - 5 - 硝基咪唑 - N3）铂（II）（弗拉普）
Br J Cancer. 1982 Nov;46(5):701-5. doi: 10.1038/bjc.1982.261.
10
Chromosomal aberrations, sister chromatid exchange (SCEs) and micronuclei induction with three platinum compounds (cis-DDP, CHIP, CBDCA) in V79 cells in vitro.
Neoplasma. 1984;31(6):655-9.

引用本文的文献

1
Sister chromatid exchanges induced by two radiosensitizing platinum compounds (cis-dichloro-bis isopropylamine trans dihydroxy platinum IV (CHIP) and cis platinum metronidazole2Cl2(FLAP)) in CHO cells in vitro.两种放射增敏铂化合物（顺式二氯双异丙胺反式二羟基铂IV（CHIP）和顺铂甲硝唑2Cl2（FLAP））在体外诱导CHO细胞中的姐妹染色单体交换。
Br J Cancer. 1983 Dec;48(6):803-7. doi: 10.1038/bjc.1983.270.
2
Evaluation of trans-tetrachloro-1,2-diaminocyclohexane platinum (IV) in murine leukemia L1210 resistant and sensitive to cis-diamminedichloroplatinum (II).
Cancer Chemother Pharmacol. 1987;20(2):96-100. doi: 10.1007/BF00253961.
3
Advances in platinum cancer chemotherapy. Advances in the design of cisplatin analogues.铂类癌症化疗的进展。顺铂类似物设计的进展。
Cancer Metastasis Rev. 1988 Apr;7(1):67-89. doi: 10.1007/BF00048279.
4
Evaluation of CHIP (iproplatin) in recurrent pediatric malignant solid tumors. A phase II study (Pediatric Oncology Group).顺氯氨铂（异环磷酰胺铂）用于复发性儿童恶性实体瘤的评估。一项II期研究（儿童肿瘤研究组）
Invest New Drugs. 1992 Jul;10(2):93-6. doi: 10.1007/BF00873123.

本文引用的文献

1
Growth and nucleic acid synthesis in synchronously dividing populations of HeLa cells.同步分裂的海拉细胞群体中的生长与核酸合成
Exp Cell Res. 1963 Apr;30:344-62. doi: 10.1016/0014-4827(63)90306-9.
2
A quantitative comparison of cytogenetic effects of anti-tumor agents.
Cytogenet Cell Genet. 1982;33(1-2):27-34. doi: 10.1159/000131722.
3
Premature chromosome condensation. II. The nature of chromosome gaps produced by alkylating agents and ultraviolet light.
Mutat Res. 1974 May;23(2):259-66. doi: 10.1016/0027-5107(74)90146-8.
4
Endoreduplication in cultured mammalian cells treated with 4-nitroquinoline I-oxide.用4-硝基喹啉1-氧化物处理的培养哺乳动物细胞中的核内复制。
Mutat Res. 1973 May;18(2):171-8. doi: 10.1016/0027-5107(73)90033-x.
5
New platinum complexes with anti-tumour activity.
Chem Biol Interact. 1972 Nov;5(6):415-24. doi: 10.1016/0009-2797(72)90078-6.
6
Cross-linking of complementary strands of DNA in mammalian cells by antitumour platinum compounds.抗肿瘤铂化合物对哺乳动物细胞中DNA互补链的交联作用。
Nature. 1972 Feb 4;235(5336):282-4. doi: 10.1038/235282a0.
7
The relationship between chromosomal aberrations, survival and DNA repair in tumour cell lines of differential sensitivity to X-rays and sulphur mustard.
Mutat Res. 1974 Feb;22(2):207-21. doi: 10.1016/0027-5107(74)90101-8.
8
Mechanisms of chromosomal aberration production. 3. Chemicals and ionizing radiation.
Mutat Res. 1974 May;23(2):197-212. doi: 10.1016/0027-5107(74)90140-7.
9
Mechanisms of chromosomal aberration production. I. Aberration induction by ultraviolet light.染色体畸变产生的机制。I. 紫外线诱导的畸变
Mutat Res. 1973 Dec;20(3):387-402. doi: 10.1016/0027-5107(73)90060-2.
10
Post-replication repair of DNA in Chinese hamster cells treated with cis platinum (II) diamine dichloride. Enhancement of toxicity and chromosome damage by caffeine.
Mutat Res. 1975 Dec;33(2-3):279-84. doi: 10.1016/0027-5107(75)90203-1.

通过分析染色体畸变产生来研究顺二氯双（异丙胺）反二羟基铂（IV）（CHIP）的作用方式。

The mode of action of cis dichloro-bis (isopropylamine) trans dihydroxy platinum IV (CHIP) studied by the analysis of chromosome aberration production.

作者信息

Bocian E, Laverick M, Nias A H

出版信息

Br J Cancer. 1983 Apr;47(4):503-9. doi: 10.1038/bjc.1983.80.

DOI:10.1038/bjc.1983.80
PMID:6849795
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2011329/
Abstract

The induction of chromosome damage by the Platinum complex CHIP in Chinese hamster ovary (CHO) cells has been studied, together with the relationship between cell survival and aberration frequency. The type and frequency of chromosome aberrations observed in asynchronous and G1 phase treated cells indicated a similar mode of action to that of bifunctional alkylating agents. A log-linear relationship was observed between the frequency of chromatid aberrations (excluding gaps) and the level of survival after CHIP treatment, with approximately one aberration per cell corresponding to 37% survival.

摘要

研究了铂配合物CHIP对中国仓鼠卵巢（CHO）细胞染色体损伤的诱导作用，以及细胞存活与畸变频率之间的关系。在异步处理和G1期处理的细胞中观察到的染色体畸变类型和频率表明，其作用模式与双功能烷化剂相似。CHIP处理后，染色单体畸变（不包括裂隙）频率与存活水平之间呈对数线性关系，每细胞约一个畸变对应37%的存活率。