Christensen H N
Biosci Rep. 1983 Oct;3(10):905-13. doi: 10.1007/BF01140659.
The rate of alanine transport into the liver limits its utilization even under the high alanine load resulting from a 90% casein diet, given that the rat has been adapted to that diet. A coordinated acceleration of alanine catabolism allows transport to remain rate-limiting, which in turn allows the adaptive regulation of transport to remain effective at high alanine loads. Accelerated degradation of alanine may change the hepatic amino acid content in a way that derepresses the activity of the alanine carrier system(s).
即使在因90%酪蛋白饮食导致高丙氨酸负荷的情况下，鉴于大鼠已适应该饮食，丙氨酸转运至肝脏的速率仍限制了其利用。丙氨酸分解代谢的协同加速使转运保持限速状态，这反过来又使转运的适应性调节在高丙氨酸负荷时仍能有效发挥作用。丙氨酸的加速降解可能会改变肝脏氨基酸含量，从而解除对丙氨酸载体系统活性的抑制。
