Maire J P, Coudin B, Demeaux H, Celerier D, Guerin J, Caudry M
Bull Cancer. 1983;70(4):275-83.
Thirty adult patients treated for brain tumors by radiation therapy were tested by the Weschler intelligence scale (WAIS). All patients were in complete clinical and scanographic remission. Intellectual quotient (IQ) and deterioration coefficient were evaluated. This coefficient was determined by separate study of intellectual faculties according to their relationship to external aggressions. During the first six months, IQ and deterioration coefficient are similar to those observed in the normal population. From 7 to 30 months, there is a significant diminution of the intellectual faculties (p = 0,01) noted on the deterioration coefficient but without global IQ alteration. After 30 months appears a decrease in the global IQ, testifying of further alteration of intellectual faculties. Radiation therapy seems to be the predominant factor in the induction of this deterioration and the importance of the irradiation volume appears to be essential. On the other hand, neurosurgery, chemotherapy and emotional status seem to be less important. Intellectual deterioration makes professional reinsertion difficult but not impossible. Further studies are necessary to define what place take other factors like age, vascular status, tumor site, type and number of chemotherapy cycles, acute radiation tolerance, in the induction of this deterioration.
30名接受放射治疗的脑肿瘤成年患者接受了韦氏智力量表（WAIS）测试。所有患者在临床和扫描检查方面均完全缓解。对智商（IQ）和衰退系数进行了评估。该系数是根据智力能力与外部侵害的关系分别对其进行研究而确定的。在最初的六个月里，智商和衰退系数与正常人群中观察到的情况相似。从7到30个月，衰退系数显示智力能力有显著下降（p = 0.01），但总体智商没有改变。30个月后，总体智商出现下降，证明智力能力进一步受损。放射治疗似乎是导致这种衰退的主要因素，照射体积的大小似乎至关重要。另一方面，神经外科手术、化疗和情绪状态似乎不太重要。智力衰退使职业再融入变得困难但并非不可能。有必要进一步开展研究，以确定年龄、血管状况、肿瘤部位、化疗周期的类型和次数、急性放射耐受性等其他因素在引发这种衰退中所起的作用。
