兔膀胱底部平滑肌对河豚毒素抵抗性收缩的吲哚美辛敏感性
Sensitivity to indomethacin of tetrodotoxin-resistant contractions of smooth muscle from the base of rabbit bladder.
作者信息
Downie J W, Slack B E
出版信息
Br J Pharmacol. 1983 Jun;79(2):334-6. doi: 10.1111/j.1476-5381.1983.tb11005.x.
Abstract
Tetrodotoxin (TTX) reduced the contractions to field stimulation of strips of rabbit bladder base by 58% of control (at 40 Hz), and increased the spontaneous activity occurring between the evoked responses. The TTX-resistant contractions resembled the spontaneous activity in that they were of comparable size and poorly sustained; in the presence of indomethacin, TTX produced a significantly greater reduction (to 13% of control at 40 Hz), of the evoked contractions. Indomethacin abolished spontaneous activity in the presence and absence of TTX, but did not affect evoked responses in strips that were not exposed to TTX. The results imply that a prostaglandin-like substance may potentiate residual evoked responses in TTX-treated strips, but does not contribute to field stimulation-induced contractions in untreated bladder base smooth muscle.
摘要
河豚毒素（TTX）使兔膀胱基部条带对场刺激的收缩幅度降低至对照的58%（40Hz时），并增加了诱发反应之间出现的自发活动。对TTX耐药的收缩与自发活动相似，因为它们大小相当且持续时间短；在吲哚美辛存在的情况下，TTX对诱发收缩的降低作用显著更大（40Hz时降至对照的13%）。吲哚美辛在有或无TTX的情况下均消除了自发活动，但对未暴露于TTX的条带中的诱发反应没有影响。结果表明，一种前列腺素样物质可能增强了TTX处理条带中残留的诱发反应，但对未处理的膀胱基部平滑肌中场刺激诱导的收缩没有作用。
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