大鼠离体膀胱对甲苯二异氰酸酯收缩反应的药理学调节
Pharmacological modulation of the contractile response to toluene diisocyanate in the rat isolated urinary bladder.
作者信息
Mapp C E, Chitano P, Fabbri L M, Patacchini R, Maggi C A
机构信息
Institute of Occupational Medicine, University of Padua, Italy.
出版信息
Br J Pharmacol. 1990 Aug;100(4):886-8. doi: 10.1111/j.1476-5381.1990.tb14109.x.
Abstract
- Toluene diisocyanate produced concentration-dependent contractions of the rat isolated urinary bladder. 2. The contractions were tetrodotoxin-resistant and were abolished by previous exposure of the strips to capsaicin. 3. Indomethacin (5 microM) and ruthenium red (30 microM) inhibited toluene diisocyanate-induced contractions. Responses expressed as a percentage of the response obtained with substance P, 30 nM, were respectively 141.6 +/- 24.8% and 20.1 +/- 5.1% in control and indomethacin-treated strips (P less than 0.005); 123.0 +/- 30.2% and 14.0 +/- 6.5% in control and ruthenium red-treated strips (0.01 less than P less than 0.05). 4. These results suggest that toluene diisocyanate-induced contractions of the rat isolated bladder are the result of the release of cyclo-oxygenase products which may act by activating the capsaicin receptor.
摘要
- 甲苯二异氰酸酯可使大鼠离体膀胱产生浓度依赖性收缩。2. 这些收缩对河豚毒素具有抗性，且在将膀胱条预先暴露于辣椒素后消失。3. 吲哚美辛（5微摩尔）和钌红（30微摩尔）可抑制甲苯二异氰酸酯诱导的收缩。以30纳摩尔P物质所获反应的百分比表示反应，在对照和吲哚美辛处理的膀胱条中分别为141.6±24.8%和20.1±5.1%（P＜0.005）；在对照和钌红处理的膀胱条中分别为123.0±30.2%和14.0±6.5%（0.01＜P＜0.05）。4. 这些结果表明，甲苯二异氰酸酯诱导的大鼠离体膀胱收缩是环氧化酶产物释放的结果，这些产物可能通过激活辣椒素受体起作用。
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本文引用的文献
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Functional evidence for the existence of a capsaicin-sensitive innervation in the rat urinary bladder.大鼠膀胱中存在辣椒素敏感神经支配的功能证据。
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