阿片类药物对钾电导的激活作用会抑制大鼠蓝斑神经元中的钙动作电位。
Opiate activation of potassium conductance inhibits calcium action potentials in rat locus coeruleus neurones.
作者信息
North R A, Williams J T
出版信息
Br J Pharmacol. 1983 Oct;80(2):225-8. doi: 10.1111/j.1476-5381.1983.tb10023.x.
Abstract
Opiates act on mu-receptors to increase the potassium conductance of rat locus coeruleus neurones. Opiates also depress the rate of rise and peak amplitude of calcium action potentials in these cells. The action of opiates on calcium action potentials was prevented by two procedures which blocked the opiate-induced potassium current, intracellular caesium and extracellular barium. This indicates that the opiate reduction in calcium entry is secondary to an increased potassium current.
摘要
阿片类药物作用于μ受体，以增加大鼠蓝斑神经元的钾电导。阿片类药物还会降低这些细胞中钙动作电位的上升速率和峰值幅度。通过两种阻断阿片类药物诱导的钾电流的方法，即细胞内铯和细胞外钡，可防止阿片类药物对钙动作电位的作用。这表明阿片类药物导致钙内流减少是钾电流增加的继发结果。
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