Bodenhoff J, Madsen P S
Acta Pathol Microbiol Scand B. 1978 Feb;86(1):51-2.
Prototheca zopfii was isolated repeatedly from milk samples from ten cows (of a herd of 192 dairy cows) with reduced milk yield and indurated mammary glands. The strain was moderately sensitive to streptomycin, polymyxin and gentamycin, but resistant or relatively resistant to other antibiotics and antimycotics commonly used in clinical practice. An attempt to treat the infection with Ethidium bromide, which was found effective in vitro, did not succeed. The number of Prototheca excreted decreased, but a complete cure was not obtained. In histological sections of the udder, Prototheca cells were demonstrated both intracellularly and interstitially.
从192头奶牛群中10头产奶量下降且乳腺硬结的奶牛的牛奶样本中反复分离出佐夫原藻。该菌株对链霉素、多粘菌素和庆大霉素中度敏感，但对临床实践中常用的其他抗生素和抗真菌药耐药或相对耐药。用在体外被发现有效的溴化乙锭治疗感染的尝试未成功。排出的原藻数量减少，但未完全治愈。在乳房的组织切片中，原藻细胞在细胞内和间质中均有显示。
