Hendry W F, Stedronska J, Jones C R, Blackmore C A, Barrett A, Peckham M J
Br J Urol. 1983 Dec;55(6):769-73. doi: 10.1111/j.1464-410x.1983.tb03423.x.
Over a 7-year period, seminal analysis has been performed on 208 patients with testicular tumours, after orchiectomy, but before any other treatment. Only 22% of 54 patients with seminomas, and 29% of 154 patients with teratomas or mixed tumours, had sperm counts exceeding 10 million per ml. Very low sperm counts were observed in some patients who had previously fathered children. Post-treatment sperm counts were done in 117 patients, 80 of whom had received multiple drug chemotherapy: 42 of these men had pre- and post-treatment sperm counts. Overall, 24% of men receiving chemotherapy recovered sperm counts greater than 10 million per ml up to 3 years after therapy. Surprisingly, such recovery was seen in 35% of 23 men with initially poor sperm counts, but in only 26% of 19 with good initial counts. Only 27% of 49 patients with Hodgkin's disease had initial sperm counts of more than 10 million per ml; after chemotherapy only 1 of 29 patients recovered to this level. Only one quarter of these young men had semen which was adequate for cryopreservation. Artificial insemination with semen preserved in liquid nitrogen has been performed in 15 couples: 2 normal babies have been produced and a third pregnancy is progressing normally.
在7年的时间里，对208例睾丸肿瘤患者在睾丸切除术后、但在接受任何其他治疗之前进行了精液分析。54例精原细胞瘤患者中只有22%，154例畸胎瘤或混合性肿瘤患者中只有29%的精子计数超过每毫升1000万。在一些曾育有子女的患者中观察到精子计数极低。对117例患者进行了治疗后的精子计数，其中80例接受了多药化疗：这些男性中有42例进行了治疗前和治疗后的精子计数。总体而言，接受化疗的男性中有24%在治疗后3年内精子计数恢复到每毫升超过1000万。令人惊讶的是，最初精子计数较差的23名男性中有35%出现了这种恢复，但最初计数良好的19名男性中只有26%出现这种情况。49例霍奇金病患者中只有27%的初始精子计数超过每毫升1000万；化疗后，29例患者中只有1例恢复到这个水平。这些年轻男性中只有四分之一的精液适合冷冻保存。已对15对夫妇进行了用液氮保存的精液进行人工授精：已产下2名正常婴儿，第三次妊娠进展正常。
