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灌注脑室的液体中钙离子(Ca++)和镁离子(Mg++)浓度升高以及缺氧对诱发性舌肌抽搐的影响。

Effect of increased concentrations of ca++ and mg++ in the fluid perfusing the cerebral ventricles, and hypoxia on evoked tongue jerks.

作者信息

Leśnik H, Traczyk W Z

出版信息

Acta Physiol Pol. 1978 Jan-Feb;29(1):27-35.

PMID:665247
Abstract

Effect of increased concentrations of Ca++ and Mg++ in the fluid perfusing the cerebral ventricles, and hypoxia on evoked tongue jerks. Acta Physiol. Pol., 1978, 29 (1): 27-36. The infraorbital nerve, the sensory part of the trigeminal nerve, was stimulated in rats under chloralose anaesthesia. Electric stimuli of 0.2 Hz caused retractive movements of the stretched tongue. These evoked tongue jerks (ETJ) were recorded directly on a kymograph or on a linear recorder. Using a stereotaxic apparatus cannulas were inserted into both lateral ventricles of the brain for infusion of McIlwain-Rodnight's fluid at a rate of about 50 microliter/minute. The cannula for outflow of the perfusing fluid was inserted into the cerebellomedullary cistern. The ETJ was enhanced by 43%, on the average, during perfusion of the cerebral ventricles with solutions with fivefold increased concentration of calcium ions, and decreased by a mean value 24% when the perfusing solution contained a higher concentration of magnesium ions. After 10 min of breathing with increased respiratory dead space, which caused hypoxia and hypercapnia, the amplitude of ETJ diminished by 65%, on the average.

摘要

灌流脑室的液体中钙离子和镁离子浓度升高以及缺氧对诱发舌肌抽搐的影响。《波兰生理学报》,1978年,29(1):27 - 36。在水合氯醛麻醉的大鼠中刺激三叉神经感觉部分眶下神经。0.2赫兹的电刺激引起伸展舌的回缩运动。这些诱发的舌肌抽搐(ETJ)直接记录在记纹鼓或线性记录仪上。使用立体定位仪将套管插入大脑的两个侧脑室,以约50微升/分钟的速度注入麦基尔韦恩 - 罗德奈特液。灌流液流出的套管插入小脑延髓池。在用钙离子浓度增加五倍的溶液灌流脑室期间,ETJ平均增强43%,而当灌流液含有较高浓度的镁离子时,ETJ平均降低24%。在呼吸死腔增加10分钟导致缺氧和高碳酸血症后,ETJ的幅度平均减小65%。

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