Tieman D G, Tumosa N, Tieman S B
Brain Res. 1983 Nov 28;280(1):41-50. doi: 10.1016/0006-8993(83)91171-x.
To compare the effects of monocular deprivation produced by occlusion and diffusion, 9 cats were reared in the dark from birth to 4 weeks of age, when they were brought out for periods of exposure with one eye covered. For 3 cats, the left eye was covered with a white diffuser while the right eye received 8 h of normal patterned exposure (MD/D-8). For 2 cats, the left eye was covered with a black occluder while the right eye was exposed for 8 h (MD/O-8), and for 4 cats, the right eye was covered with a black occluder while the left eye was exposed for 1 h (MD/O-1). Monocular exposure continued until the cats were 3 months old, when they began receiving binocular exposure. For all cats, the visual field of the exposed eye was normal. For the MD/D cats, the field of the pattern-deprived eye was restricted to the monocular crescent, and resembled the fields of monocularly lid-sutured cats. In contrast, for the MD/O cats, the field of the pattern-deprived eye was much larger, extending nearly to the midline. Thus, monocular diffusion produced more restricted visual fields than did monocular occlusion. Preliminary physiological data from the MD/D-8 and MD/O-8 cats showed that more cortical cells responded to stimulation of the pattern-deprived eye in the MD/O-8 cats than in the MD/D-8 cats. Taken together with our earlier results on cats reared with unequal patterned input to the two eyes, these results further suggest that there is a temporal-to-nasal gradient in sensitivity to the effects of an imbalance in stimulation to the two eyes.
为比较遮盖和弥散造成的单眼剥夺效应，9只猫从出生到4周龄时饲养在黑暗环境中，之后将它们带出，每次让一只眼睛暴露一定时间。对于3只猫，左眼覆盖白色弥散片，右眼接受8小时正常的有图案视觉刺激（MD/D - 8）。对于2只猫，左眼覆盖黑色眼罩，右眼暴露8小时（MD/O - 8），对于4只猫，右眼覆盖黑色眼罩，左眼暴露1小时（MD/O - 1）。单眼暴露持续到猫3个月大，之后开始双眼暴露。所有猫中，暴露眼的视野正常。对于MD/D组的猫，图案剥夺眼的视野局限于单眼半月形区域，类似于单眼眼睑缝合猫的视野。相比之下，对于MD/O组的猫，图案剥夺眼的视野要大得多，几乎延伸到中线。因此，单眼弥散比单眼遮盖产生的视野受限更严重。来自MD/D - 8和MD/O - 8组猫的初步生理学数据表明，MD/O - 8组猫中对图案剥夺眼刺激产生反应的皮层细胞比MD/D - 8组猫更多。结合我们早期关于两只眼睛接受不等量有图案输入饲养的猫的研究结果，这些结果进一步表明，两只眼睛刺激不平衡的影响在敏感度上存在从颞侧到鼻侧的梯度。
