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关于区域性休克时猫小肠释放的血源性心脏毒性物质的化学性质

On the chemical nature of the blood borne cardiotoxic material released from the feline small bowel in regional shock.

作者信息

Lundgren O, Haglund U

出版信息

Acta Physiol Scand. 1978 May;103(1):59-70. doi: 10.1111/j.1748-1716.1978.tb06191.x.

DOI:10.1111/j.1748-1716.1978.tb06191.x
PMID:665260
Abstract

The cardiotoxic material released into blood from the feline small intestine during a 2 or 3 h regional shock period (inflow pressure to the small intestine 30--35 mmHg during a continuous activation of the regional sympathetic vasoconstrictor fibres at 6 Hz) has been analyzed with regard to three properties: 1. molecular mass determined by molecular filtrations; 2. solubility in a nonpolar solvent (ether); 3. heat stability by heating plasma to 80 degrees C for 30 min. The results obtained suggest that the cardiotoxic material consists of at least two heat stable fractions. One is water soluble with a molecular mass between 500 and 1 000 d and the other is lipid soluble with an unknown molecular mass.

摘要

在2至3小时的局部休克期(在6赫兹持续激活局部交感缩血管纤维期间,小肠的流入压力为30 - 35毫米汞柱),从猫小肠释放到血液中的心脏毒性物质已针对三个特性进行了分析:1. 通过分子过滤测定的分子量;2. 在非极性溶剂(乙醚)中的溶解度;3. 通过将血浆加热至80摄氏度30分钟来测定热稳定性。所得结果表明,心脏毒性物质至少由两个热稳定组分组成。一种是水溶性的,分子量在500至1000道尔顿之间,另一种是脂溶性的,分子量未知。

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