Haglund U, Lundgren O
Fed Proc. 1978 Nov;37(13):2729-33.
Perfusion pressure reduction to the small intestinal vascular bed for 2 hours to followed by characteristic villous damage and a general cardiovascular derangement. In an extensive series of experiments on cats it was demonstrated that the cardiovascular derangement could not be ascribed to any pooling of blood and/or fluid in the small intestine. Cardiotoxic material has been demonstrated in the cat intestinal venous blood in in vivo and in vitro experiments using working rat hearts and isolated rabbit papillary muscles. A relationship between the extent of the villous damage and the appearance of cardiotoxic material in the intestinal venous blood has been found. The cardiotoxic material seems to consist of at least two heat stable fractions. One is water soluble with a molecular mass between 500 and 1,000 daltons and the other is lipid soluble with an unknown molecular mass.
小肠血管床灌注压力降低2小时后，会出现典型的绒毛损伤和全身性心血管紊乱。在对猫进行的一系列广泛实验中表明，心血管紊乱不能归因于小肠内血液和/或液体的任何蓄积。在体内和体外实验中，使用工作大鼠心脏和分离的兔乳头肌，已在猫的肠静脉血中证实了心脏毒性物质。已发现绒毛损伤程度与肠静脉血中心脏毒性物质的出现之间存在关联。心脏毒性物质似乎至少由两个热稳定组分组成。一种是水溶性的，分子量在500至1000道尔顿之间，另一种是脂溶性的，分子量未知。
