系统性红斑狼疮患者血清中补体介导的免疫复合物溶解能力降低以及存在未完全溶解的免疫复合物。
Reduced complement-mediated immune complex solubilizing capacity and the presence of incompletely solubilized immune complexes in SLE sera.
作者信息
Baatrup G, Petersen I, Jensenius J C, Svehag S E
出版信息
Clin Exp Immunol. 1983 Nov;54(2):439-47.
Reduced complement-mediated solubilization (CMS) of pre-formed immune complexes (IC) was demonstrated in sera from 11 out of 12 SLE patients. The presence of incompletely solubilized endogeneous IC in SLE sera was indicated by the following findings: (1) When IC positive SLE sera with reduced CMS capacity were mixed with normal donor sera they inhibited the CMS of the latter sera. (2) Resuspended PEG (2.75%) precipitates obtained from SLE sera inhibited the CMS of normal donor sera. (3) Non-solubilized or incompletely complement solubilized IC in SLE sera give a strong response in the PEG-CC assay for IC. The IC activity of SLE sera was clearly reduced in this assay when the endogeneous IC were solubilized prior to testing. In contrast, sera of 14 rheumatoid arthritis (RA) patients exhibited normal CMS. IC which could be further solubilized by complement were not demonstrable although all RA sera were IC positive.
12例系统性红斑狼疮（SLE）患者中，11例患者血清中预先形成的免疫复合物（IC）的补体介导溶解作用（CMS）降低。SLE血清中存在未完全溶解的内源性IC可通过以下发现表明：（1）当CMS能力降低的IC阳性SLE血清与正常供体血清混合时，它们会抑制后者血清的CMS。（2）从SLE血清中重新悬浮的聚乙二醇（2.75%）沉淀物抑制正常供体血清的CMS。（3）SLE血清中未溶解或补体未完全溶解的IC在IC的聚乙二醇-补体结合试验（PEG-CC试验）中产生强烈反应。当内源性IC在测试前溶解时，SLE血清的IC活性在该试验中明显降低。相比之下，14例类风湿性关节炎（RA）患者的血清表现出正常的CMS。尽管所有RA血清IC均为阳性，但未发现可被补体进一步溶解的IC。
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