Ramanathan V D, Sharma P, Ramu G, Sengupta U
Clin Exp Immunol. 1985 Jun;60(3):553-8.
The ability of sera from leprosy patients to solubilize immune precipitates in vitro through the complement system was studied. The solubilizing capacity of sera from patients who did not have any reactions during 2 years or more after starting chemotherapy was comparable with that of normal laboratory volunteers. On the other hand, sera from borderline tuberculoid and lepromatous leprosy patients in reaction had markedly decreased levels of solubilization. Their total and the alternative pathway haemolytic levels did not show a corresponding decrease. Although the circulating immune complexes and serum C3d of these patients came down after the subsidence of reaction, their solubilization remained consistently low during a 3 month follow-up period.
研究了麻风病人血清通过补体系统在体外溶解免疫沉淀物的能力。开始化疗后两年或更长时间内无任何反应的病人血清的溶解能力与正常实验室志愿者的相当。另一方面，处于反应期的界线类偏结核型和瘤型麻风病人的血清溶解水平明显降低。他们的总溶血水平和替代途径溶血水平并未相应降低。虽然这些病人的循环免疫复合物和血清C3d在反应消退后下降，但在3个月的随访期内其溶解能力一直很低。
