Naama J K, Mitchell W S, Zoma A, Veitch J, Whaley K
Clin Exp Immunol. 1983 Feb;51(2):292-8.
The ability of human sera to prevent the precipitation of antigen-antibody complexes has been investigated. The early complement components including C3 are required for optimal prevention of immune precipitation, whereas the later components are not required. The sera of 36 of 75 patients with seropositive rheumatoid arthritis (RA), 14 of 32 with SLE and four of 17 with glomerulonephritis exhibited reduced capacities to prevent immune precipitation. In contrast sera from patients with seronegative RA, ankylosing spondylitis, psoriatic arthritis or degenerative joint disease were normal in this respect. In SLE and GN sera hypocomplementaemia was frequently associated but not always with failure to prevent immune precipitation, whereas only a small proportion of the patients with seropositive RA and reduced capacity to retain complexes in a soluble form were hypocomplementaemic. Thus the failure of sera to prevent the precipitation of antigen-antibody complexes is not always associated with hypocomplementaemia.
已对人血清阻止抗原-抗体复合物沉淀的能力进行了研究。早期补体成分（包括C3）是最佳阻止免疫沉淀所必需的，而后期成分则不需要。75例血清反应阳性类风湿性关节炎（RA）患者中的36例、32例系统性红斑狼疮（SLE）患者中的14例以及17例肾小球肾炎患者中的4例，其血清阻止免疫沉淀的能力降低。相比之下，血清反应阴性的RA、强直性脊柱炎、银屑病关节炎或退行性关节病患者的血清在这方面是正常的。在SLE和肾小球肾炎患者血清中，补体减少症经常出现，但并不总是与无法阻止免疫沉淀相关，而血清反应阳性的RA患者中，只有一小部分以可溶形式保留复合物能力降低的患者存在补体减少症。因此，血清无法阻止抗原-抗体复合物沉淀并不总是与补体减少症相关。
