Ravnskov U
Acta Med Scand. 1978;203(5):351-6. doi: 10.1111/j.0954-6820.1978.tb14888.x.
Fifteen patients with evidence of acute poststreptococcal glomerulonephritis were asked about their contact with vapours of organic solvents. Six patients reported brief exposure shortly before the onset of glomerulonephritis, 4 fairly long exposure, and 5 none or insignificant. At the latest followup, 3 of 4 patients who were still exposed to such solvents had proteinuria and a low glomerular filtration rate (GFR), and 2 were hypertensive. Of the 11 patients who had never been or were no longer exposed, the GFR was insignificantly decreased in 2, none had proteinuria and none were hypertensive. Fifteen age-and sex-matched controls, who had been infected with group A beta-hemolytic streptococci, T type 12, had not been exposed, or the exposure was insignificant and not related to the streptococcal infection. Exposure to organic solvents or other nephrotoxic agents may be the condition which determines the outcome of an infection with nephritogenic streptococci.
15例有急性链球菌感染后肾小球肾炎证据的患者被询问其与有机溶剂蒸气的接触情况。6例患者报告在肾小球肾炎发病前不久有过短暂接触，4例有较长时间接触，5例无接触或接触不显著。在最近一次随访时，4例仍接触此类溶剂的患者中有3例出现蛋白尿且肾小球滤过率（GFR）降低，2例有高血压。在11例从未接触或不再接触的患者中，2例GFR有不显著降低，无1例有蛋白尿，也无1例有高血压。15名年龄和性别匹配的对照者感染了A组β溶血性链球菌，T12型，未接触过有机溶剂，或接触不显著且与链球菌感染无关。接触有机溶剂或其他肾毒性物质可能是决定致肾炎性链球菌感染预后的条件。
