Hulthén U L, Lecerof H, Hökfelt B
Acta Med Scand. 1978;203(5):411-4. doi: 10.1111/j.0954-6820.1978.tb14897.x.
The effect of tilting on the release of renal kallikrein as compared to renin was studied by the determination of kinin concentration and plasma renin activity (PRA) in the renal veins in supine position and after 15 min of 45 degrees upright tilting in 10 patients with essential hypertension. Kinin concentration decreased from 0.62 +/- 0.05 microgram/1 (mean +/- S.E.M.) in supine position to 0.51 +/- 0.05 after tilting (p less than 0.01), while PRA increased from 2.84 +/- 0.39 microgram/1/3 h tpo 4.87 +/- 0.66 (p less than 0.001). These results indicate that tilting diminishes the release of renal kallikrein. It is suggested that decreased intrarenal generation of kinins may be of importance for the reduction of diuresis and natriuresis induced by tilting.
通过测定10例原发性高血压患者仰卧位及45度直立倾斜15分钟后肾静脉中的激肽浓度和血浆肾素活性（PRA），研究了倾斜对肾激肽释放酶与肾素释放的影响。激肽浓度从仰卧位时的0.62±0.05微克/升（均值±标准误）降至倾斜后的0.51±0.05微克/升（p<0.01），而PRA从2.84±0.39微克/升/3小时增至4.87±0.66微克/升（p<0.001）。这些结果表明倾斜会减少肾激肽释放酶的释放。提示肾内激肽生成减少可能对倾斜诱导的利尿和利钠作用的降低具有重要意义。
