Denniston C
Environ Health Perspect. 1983 Oct;52:41-4. doi: 10.1289/ehp.835241.
The concept of the mutation component of a genetic trait is discussed and its relation to heritability investigated. It is found that for qualitative traits held in the population by opposing directional selection and mutation, the mutation component equals the broad sense heritability. The mutational component of a quantitative trait with an intermediate optimum is found generally to be between half and one times the (narrow sense) heritability of the character. Although more work on this matter is required, the finding of a relationship between mutation component and heritability should allow us to make better predictions regarding the likely impact of an increased mutation rate on the human population. Some statistical problems relevant to the detection of an increased mutation rate are also discussed.
本文讨论了遗传性状突变成分的概念，并研究了其与遗传力的关系。研究发现，对于由反向定向选择和突变在群体中维持的质量性状，突变成分等于广义遗传力。一般发现，具有中间最优值的数量性状的突变成分在该性状（狭义）遗传力的一半到一倍之间。尽管在这个问题上还需要更多的研究，但突变成分与遗传力之间关系的发现应该使我们能够更好地预测突变率增加对人类群体可能产生的影响。还讨论了与检测突变率增加相关的一些统计问题。
