由多效突变维持的性状间遗传协方差。
The Genetic Covariance between Characters Maintained by Pleiotropic Mutations.
机构信息
Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin.
出版信息
Genetics. 1980 Jan;94(1):203-15. doi: 10.1093/genetics/94.1.203.
Abstract
A statistical genetic model of a multivariate phenotype is derived to investigate the covariation of pleiotropic mutations with additive effects under the combined action of phenotypic selection, linkage and the mating system. Equilibrium formulas for large, randomly mating populations demonstrate that, when selection on polygenic variation is much smaller than twice the harmonic mean recombination rate between loci with interacting fitnesses, linkage disequilibrium is negligible and pleiotropy is the main cause of genetic correlations between characters. Under these conditions, approximate expressions for the dynamics of the genetic covariances due to pleiotropic mutations are obtained. Patterns of genetic covariance between characters and their evolution are discussed with reference to data on polygenic mutation, chromosomal organization and morphological integration.
摘要
为了研究表型选择、连锁和交配系统共同作用下，多效突变与加性效应的共变，本文构建了一个多变量表型的统计遗传模型。对于大型随机交配群体的平衡公式表明，当多基因变异的选择远小于具有相互作用适应性的基因座之间的调和平均重组率的两倍时，连锁不平衡可以忽略不计，多效性是性状间遗传相关性的主要原因。在这些条件下，获得了由多效突变引起的遗传协方差的动态近似表达式。本文还参考了多基因突变、染色体组织和形态整合方面的数据，讨论了性状间遗传协方差的模式及其进化。
相似文献
1
The Genetic Covariance between Characters Maintained by Pleiotropic Mutations.由多效突变维持的性状间遗传协方差。
Genetics. 1980 Jan;94(1):203-15. doi: 10.1093/genetics/94.1.203.
2
Effects of pleiotropy on predictions concerning mutation-selection balance for polygenic traits.多效性对多基因性状突变-选择平衡预测的影响。
Genetics. 1985 Sep;111(1):165-95. doi: 10.1093/genetics/111.1.165.
3
Variation in pleiotropy and the mutational underpinnings of the G-matrix.多效性的变异以及G矩阵的突变基础。
Evolution. 2006 Dec;60(12):2655-60.
4
RESPONSE TO SELECTION IN PARTIALLY SELF-FERTILIZING POPULATIONS. II. SELECTION ON MULTIPLE TRAITS.部分自花受精种群中对选择的响应。II. 对多个性状的选择
Evolution. 1999 Apr;53(2):350-357. doi: 10.1111/j.1558-5646.1999.tb03771.x.
5
Epistatic pleiotropy and the genetic architecture of covariation within early and late-developing skull trait complexes in mice.上位性多效性与小鼠早期和晚期发育的颅骨性状复合体中共变量的遗传结构
Genetics. 2005 Oct;171(2):683-94. doi: 10.1534/genetics.104.038885. Epub 2005 Jul 14.
6
Pleiotropic overdominance and the maintenance of genetic variation in polygenic characters.多效超显性与多基因性状遗传变异的维持
Genetics. 1984 Jun;107(2):321-30. doi: 10.1093/genetics/107.2.321.
7
Additive variation maintained under stabilizing selection: a two-locus model of pleiotropy for two quantitative characters.在稳定选择下维持的加性变异：两个数量性状的多效性双位点模型。
Genetics. 1986 Mar;112(3):717-25. doi: 10.1093/genetics/112.3.717.
8
OPTIMIZATION MODELS, QUANTITATIVE GENETICS, AND MUTATION.优化模型、数量遗传学与突变
Evolution. 1990 May;44(3):520-538. doi: 10.1111/j.1558-5646.1990.tb05936.x.
9
Pleiotropic stabilizing selection limits the number of polymorphic loci to at most the number of characters.多效性稳定选择将多态位点的数量限制为最多与性状数量相同。
Genetics. 1989 Jun;122(2):459-63. doi: 10.1093/genetics/122.2.459.
10
Comparative methods with sampling error and within-species variation: contrasts revisited and revised.考虑抽样误差和种内变异的比较方法：对比的重新审视与修订
Am Nat. 2008 Jun;171(6):713-25. doi: 10.1086/587525.
引用本文的文献
1
Conserved wing shape variation across biological scales unveils dialectical relationships between micro- and macroevolution.跨生物尺度的保守翅形变异揭示了微观和宏观进化之间的辩证关系。
Commun Biol. 2025 Jul 7;8(1):990. doi: 10.1038/s42003-025-08376-2.
2
Alternative Mutational Architectures Producing Identical M-Matrices can Lead to Different Patterns of Evolutionary Divergence.产生相同M矩阵的替代突变结构可导致不同的进化分歧模式。
Genome Biol Evol. 2025 May 30;17(6). doi: 10.1093/gbe/evaf099.
3
Specialization of male reproductive tactics correspond with large gonads and small brains.雄性生殖策略的特化与大性腺和小大脑相对应。
bioRxiv. 2025 Mar 25:2025.03.22.644732. doi: 10.1101/2025.03.22.644732.
4
Alternative mutational architectures producing identical -matrices can lead to different patterns of evolutionary divergence.产生相同 -矩阵的替代突变结构可导致不同的进化分歧模式。
bioRxiv. 2024 Dec 5:2023.08.11.553044. doi: 10.1101/2023.08.11.553044.
5
Phenotypic stasis with genetic divergence.表型停滞与遗传分化。
Peer Community J. 2023;3. doi: 10.24072/pcjournal.349. Epub 2023 Dec 12.
6
Rapid evolutionary change in trait correlations of single proteins.单蛋白性状相关性的快速进化变化。
Nat Commun. 2024 Apr 18;15(1):3327. doi: 10.1038/s41467-024-46658-1.
7
Fisher's Geometric Model as a Tool to Study Speciation.Fisher 几何模型作为研究物种形成的工具。
Cold Spring Harb Perspect Biol. 2024 Jul 1;16(7):a041442. doi: 10.1101/cshperspect.a041442.
8
Still little evidence sex differences in spatial navigation are evolutionary adaptations.目前仍缺乏证据表明空间导航中的性别差异是进化适应的结果。
R Soc Open Sci. 2024 Jan 17;11(1):231532. doi: 10.1098/rsos.231532. eCollection 2024 Jan.
9
Evolutionary relationships between metabolism and behaviour require genetic correlations.新陈代谢和行为之间的进化关系需要遗传相关性。
Philos Trans R Soc Lond B Biol Sci. 2024 Feb 26;379(1896):20220481. doi: 10.1098/rstb.2022.0481. Epub 2024 Jan 8.
10
Detecting natural selection in trait-trait coevolution.检测性状-性状协同进化中的自然选择。
BMC Ecol Evol. 2023 Sep 12;23(1):50. doi: 10.1186/s12862-023-02164-4.
本文引用的文献
1
Mutations Affecting Quantitative Traits in the Selfed Progeny of Doubled Monoploid Maize Stocks.影响双单倍体玉米自交后代数量性状的突变
Genetics. 1960 Jul;45(7):855-66. doi: 10.1093/genetics/45.7.855.
2
The Results of Crosses between Inbred Strains of Guinea Pigs, Differing in Number of Digits.豚鼠近交系之间杂交的结果，其指（趾）数不同。
Genetics. 1934 Nov;19(6):537-51. doi: 10.1093/genetics/19.6.537.
3
THE GENETIC STRUCTURE OF NATURAL POPULATIONS OF DROSOPHILA MELANOGASTER. I. SPONTANEOUS MUTATION RATE OF POLYGENES CONTROLLING VIABILITY.黑腹果蝇自然种群的遗传结构。I. 控制生活力的多基因的自发突变率。
Genetics. 1964 Jul;50(1):1-19. doi: 10.1093/genetics/50.1.1.
4
Quantitative gnetics of skeletal variations in the mouse. II. Crosses between four inbred strains (C3H, DBA, C57BL, BALB/c).小鼠骨骼变异的数量遗传学。II. 四个近交系（C3H、DBA、C57BL、BALB/c）之间的杂交
Genetics. 1962 Aug;47(8):1085-96. doi: 10.1093/genetics/47.8.1085.
5
Autonomous pleiotropy in Drosophilia.果蝇中的自主多效性。
Proc Natl Acad Sci U S A. 1968 Aug;60(4):1252-9. doi: 10.1073/pnas.60.4.1252.
6
Mutation rate and dominance of genes affecting viability in Drosophila melanogaster.影响黑腹果蝇生存力的基因的突变率及显性
Genetics. 1972 Oct;72(2):335-55. doi: 10.1093/genetics/72.2.335.
7
Substrate-specific enzyme variation in natural populations of Drosophila pseudoobscura.拟暗果蝇自然种群中底物特异性酶的变异
Genetics. 1976 Mar 25;82(3):507-26. doi: 10.1093/genetics/82.3.507.
8
Conservation of autosomal gene synteny groups in mouse and man.小鼠和人类常染色体基因同线性群的保守性。
Nature. 1978 Jul 13;274(5667):160-3. doi: 10.1038/274160a0.
Zotero 插件