Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin.
Genetics. 1980 Jan;94(1):203-15. doi: 10.1093/genetics/94.1.203.
A statistical genetic model of a multivariate phenotype is derived to investigate the covariation of pleiotropic mutations with additive effects under the combined action of phenotypic selection, linkage and the mating system. Equilibrium formulas for large, randomly mating populations demonstrate that, when selection on polygenic variation is much smaller than twice the harmonic mean recombination rate between loci with interacting fitnesses, linkage disequilibrium is negligible and pleiotropy is the main cause of genetic correlations between characters. Under these conditions, approximate expressions for the dynamics of the genetic covariances due to pleiotropic mutations are obtained. Patterns of genetic covariance between characters and their evolution are discussed with reference to data on polygenic mutation, chromosomal organization and morphological integration.
为了研究表型选择、连锁和交配系统共同作用下，多效突变与加性效应的共变，本文构建了一个多变量表型的统计遗传模型。对于大型随机交配群体的平衡公式表明，当多基因变异的选择远小于具有相互作用适应性的基因座之间的调和平均重组率的两倍时，连锁不平衡可以忽略不计，多效性是性状间遗传相关性的主要原因。在这些条件下，获得了由多效突变引起的遗传协方差的动态近似表达式。本文还参考了多基因突变、染色体组织和形态整合方面的数据，讨论了性状间遗传协方差的模式及其进化。
