吗啡可增强大鼠中由γ-氨基丁酸（GABA）拮抗剂诱发的癫痫发作，并减轻由电击诱发的癫痫发作。

Morphine potentiates seizures induced by GABA antagonists and attenuates seizures induced by electroshock in the rat.

作者信息

Foote F, Gale K

出版信息

Eur J Pharmacol. 1983 Nov 25;95(3-4):259-64. doi: 10.1016/0014-2999(83)90643-x.

Abstract

In a naloxone-reversible, dose-dependent manner, morphine (10-50 mg/kg i.p.) protected against seizures induced by maximal electroshock and increased the incidence and severity of seizures induced by bicuculline, in rats. Morphine also potentiated seizures induced by isoniazid and by picrotoxin. Thus, opiate activity influences the expression of seizures in contrasting ways depending upon the mode of seizure induction. Since morphine consistently potentiated seizures induced by interference with GABA transmission, it appears that GABAergic systems may be of particular significance for the elucidation of the varied effects of morphine on seizure susceptibility.

摘要

吗啡（10 - 50毫克/千克腹腔注射）以纳洛酮可逆、剂量依赖的方式，对大鼠最大电休克诱导的癫痫发作具有保护作用，并增加荷包牡丹碱诱导的癫痫发作的发生率和严重程度。吗啡还增强异烟肼和印防己毒素诱导的癫痫发作。因此，阿片类活性根据癫痫发作诱导方式的不同，以相反的方式影响癫痫发作的表现。由于吗啡持续增强干扰GABA传递诱导的癫痫发作，似乎GABA能系统对于阐明吗啡对癫痫易感性的多种影响可能具有特别重要的意义。