Sztriha L, Lelkes Z, Benedek G, Joó F
Naunyn Schmiedebergs Arch Pharmacol. 1986 May;333(1):47-51. doi: 10.1007/BF00569659.
The effect of morphine pretreatment on kainic acid-induced seizures in rats was investigated by electroencephalographic recording. Seizure activity was quantified by counting the number of spikes in the EEG of freely-moving rats during 2 min periods at 30 min intervals after the intraperitoneal administration of 8, 10 or 12 mg/kg kainic acid. Pretreatment with morphine (1-10 mg/kg s.c.) 10 min before kainic acid administration significantly increased the number of spikes in the EEG in a dose-dependent manner. The potentiating effect of morphine on kainic acid-induced seizures was reduced considerably, but not abolished completely by pretreatment with naloxone (2-5 mg/kg s.c.). The results indicate that the potentiating action of morphine on kainic acid-induced seizures may be exerted in both a specific, naloxone-reversible manner and a non-specific, naloxone-resistant manner.
通过脑电图记录研究了吗啡预处理对大鼠海人酸诱发癫痫发作的影响。在腹腔注射8、10或12mg/kg海人酸后，每隔30分钟在自由活动大鼠的脑电图中计数2分钟内的棘波数量，以此来量化癫痫发作活动。在注射海人酸前10分钟皮下注射吗啡（1-10mg/kg），可显著增加脑电图中的棘波数量，且呈剂量依赖性。吗啡对海人酸诱发癫痫发作的增强作用在很大程度上被纳洛酮（2-5mg/kg皮下注射）预处理所减弱，但并未完全消除。结果表明，吗啡对海人酸诱发癫痫发作的增强作用可能以特异性的、纳洛酮可逆的方式和非特异性的、纳洛酮抵抗的方式发挥作用。
