人肝脏脱铁铁蛋白的氨基酸序列。

The amino acid sequence of human liver apoferritin.

作者信息

Addison J M, Fitton J E, Lewis W G, May K, Harrison P M

出版信息

FEBS Lett. 1983 Nov 28;164(1):139-44. doi: 10.1016/0014-5793(83)80037-4.

Abstract

The protein component of the iron storage molecule, ferritin, contains 24 subunits in form of a hollow shell known as apoferritin. The amino acid sequence has been determined for apoferritin subunits from human liver. The sequence comprises 174 amino acids giving an Mr of 19 900. It shows extensive homology with the primary structures of apoferritins from human and horse spleen and from rat liver. Sequence substitutions are discussed in relation to the known three-dimensional structure of horse spleen apoferritin. Evidence for a second minor sequence in human liver apoferritin is presented.

摘要

铁储存分子铁蛋白的蛋白质成分包含24个亚基，呈中空壳状，称为脱铁铁蛋白。已确定人肝脏脱铁铁蛋白亚基的氨基酸序列。该序列由174个氨基酸组成，分子量为19900。它与来自人、马脾脏以及大鼠肝脏的脱铁铁蛋白的一级结构具有广泛的同源性。结合马脾脏脱铁铁蛋白已知的三维结构对序列替换进行了讨论。本文还提供了人肝脏脱铁铁蛋白中第二个次要序列的证据。