Santoro C, Marone M, Ferrone M, Costanzo F, Colombo M, Minganti C, Cortese R, Silengo L
Nucleic Acids Res. 1986 Apr 11;14(7):2863-76. doi: 10.1093/nar/14.7.2863.
A recently reported cDNA clone coding for human promyelocytic L apoferritin, shows some differences with a liver L apoferritin cDNA. We have investigated if these differences are due to the expression of different genes or to an alternative transcription of an unique gene. In this paper we report data suggesting that a single gene is mainly expressed in several tissues examined. This gene has been cloned and characterized. Its sequence shows three introns: the exon sequence is identical to that of cDNA clone isolated from human liver. A minimum of five related pseudogenes have been also analysed. One of them is a processed pseudogene interrupted by an intron-like fragment.
最近报道的一个编码人早幼粒细胞L-脱铁铁蛋白的cDNA克隆，与肝脏L-脱铁铁蛋白cDNA存在一些差异。我们研究了这些差异是由于不同基因的表达，还是由于单个基因的选择性转录所致。在本文中，我们报告的数据表明，在所检测的几种组织中主要表达的是单个基因。该基因已被克隆并进行了表征。其序列显示有三个内含子：外显子序列与从人肝脏分离的cDNA克隆的序列相同。还分析了至少五个相关的假基因。其中一个是被类似内含子片段中断的加工假基因。
