Hagedorn M, Stengel R
Dermatologica. 1983;167(5):234-42.
A 67-year-old male patient with typical signs of acrokeratosis Bazex is presented. The psoriasiform skin lesions appeared 9 months after diagnosis of an oesophagus neoplasm. Clinically there was a marked hepatopathy but no signs of metastases. Histological, immunofluorescence-histological, and ultrastructural findings revealed a capillaritis with humoral as well as cellular inflammation. With treatment of the neoplasm the paraneoplasia regressed under additional treatment with topical steroids. The vitamin A deficit could not be normalized by oral or parenteral vitamin A substitution. We discuss some mechanisms in formal pathogenesis.
本文报告了一名67岁患有巴泽克斯肢端角化病典型症状的男性患者。银屑病样皮肤病变在食管肿瘤诊断9个月后出现。临床上有明显的肝病，但无转移迹象。组织学、免疫荧光组织学和超微结构检查结果显示为伴有体液和细胞炎症的毛细血管炎。随着肿瘤的治疗，副肿瘤综合征在局部使用类固醇的额外治疗下消退。口服或胃肠外补充维生素A均无法使维生素A缺乏恢复正常。我们讨论了其发病机制中的一些机制。
