Zavate O, Ivan A, Avram G, Ungureanu A, Cotor F
Dev Biol Stand. 1983;54:423-7.
Two experiments on 72 888 children, out of which 36 270 received standard immunoglobulins (IG) and another 36 618 represented the control group, were carried out. IG was administered preventatively, during autumn before the occurrence of the annual peak, and in focus after contact with VH patients. Prophylactic IG administration led to a 4-14 fold decrease in the incidence of icteric VH as compared with controls, and to the disappearance of the peak characteristic of autumn-winter. The efficacy lasted for 5-6 months. The incidence of subclinical VH forms--as evaluated by clinical examinations and SGPT was about 3 times lower in IG pre-exposure recipients. In the group of children where IG was administered only to the contacts in epidemiological foci, the incidence of icteric VH remained as high in the controls and the incidence of subclinical VH forms was twice as high in the controls.
对72888名儿童进行了两项实验，其中36270名接受了标准免疫球蛋白（IG），另外36618名作为对照组。IG在秋季年度发病高峰出现之前预防性给药，并在与戊型肝炎（VH）患者接触后在疫点给药。与对照组相比，预防性给予IG导致黄疸型VH的发病率降低了4至14倍，并使秋冬特有的发病高峰消失。疗效持续5至6个月。通过临床检查和谷丙转氨酶（SGPT）评估，IG预先暴露的接受者中亚临床VH形式的发病率约低3倍。在仅对疫点接触者给予IG的儿童组中，黄疸型VH的发病率与对照组一样高，亚临床VH形式的发病率是对照组的两倍。
