Gross W
Fortschr Med. 1983 Nov 17;101(43):1995-8.
In a multicenter single-blind study on 60 patients with unilateral gonarthrosis the efficacy and tolerance of etofenamate cream were compared to a commonly used ointment containing salicylic acid and other ingredients. With respect to therapeutic success etofenamate was superior to the control medication. Mobility and circumference of the knee joint as well as pain parameters improved more rapidly in the etofenamate group, whereby the difference between both groups frequently was statistically significant. With the control medication therapy failed in three cases, with etofenamate cream clinical symptoms improved in all patients. With the exception of a transient local reddening of the skin in one patient of the etofenamate group no adverse drug reactions were observed.
在一项针对60例单侧膝关节炎患者的多中心单盲研究中，将依托芬那酯乳膏的疗效和耐受性与一种常用的含水杨酸及其他成分的软膏进行了比较。在治疗效果方面，依托芬那酯优于对照药物。依托芬那酯组膝关节的活动度、周长以及疼痛参数改善得更快，两组之间的差异常常具有统计学意义。对照药物治疗有3例失败，而使用依托芬那酯乳膏所有患者的临床症状均有改善。除依托芬那酯组有1例患者皮肤出现短暂局部发红外，未观察到药物不良反应。
