Klug H
Arzneimittelforschung. 1977;27(6B):1350-4.
Clinical trials with 2-(2-hydroxyethoxy)-ethyl-N-(a,a,a-trifluoro-m-tolyl)-anthranilate (etofenamate, active principle of Rheumon Gel) were carried out on a total of 69 patients suffering from extra-articular rheumatic complaints and painful spinal syndromes as well as from post-operative and post-accident complaints. Criteria for assessment included spontaneous pain, pressure pain and pain on movement and also limitation in joint mobility. The new gel formulation proved to have a good analgesic efficacy both in a double blind trial against placebo gel and the open study. Those patients treated with Rheumon Gel showed improvement in the symptoms spontaneous pain and pain on movement, in a large number of which patients showing improvement, in a large number of which patients showing improvement the spontaneous pain was completely eliminated. The differences in therapeutic effect compared to the placebo group as well as those of the final clinical assessment were statistically significant. Particularly good therapeutic results were observed in extra-articular rheumatic complaints and in activated arthroses. The skin tolerance of Rheumon Gel was found to be excellent. The gel form permits good and rapid penetration through the skin. The nursing staff also willingly administered the product because of its pleasant protective properties for skin and clothing.
对2-(2-羟乙氧基)乙基-N-(α,α,α-三氟间甲苯基)邻氨基苯甲酸酯（依托芬那酯，风痛凝胶的活性成分）进行了临床试验，共纳入69例患有关节外风湿性疾病、疼痛性脊柱综合征以及术后和事故后疼痛的患者。评估标准包括自发痛、压痛、运动痛以及关节活动受限。在一项针对安慰剂凝胶的双盲试验和开放研究中，新的凝胶制剂均显示出良好的镇痛效果。使用风痛凝胶治疗的患者在自发痛和运动痛症状方面有所改善，其中大量患者的自发痛完全消除。与安慰剂组相比，治疗效果的差异以及最终临床评估的差异具有统计学意义。在关节外风湿性疾病和活动性关节炎中观察到特别好的治疗效果。风痛凝胶的皮肤耐受性极佳。凝胶剂型能很好且迅速地透过皮肤。护理人员也乐意使用该产品，因为它对皮肤和衣物具有良好的保护特性。
