Flodgren P, Borgström S, Jönsson P E, Lindström C, Sjögren H O
Int J Cancer. 1983 Dec 15;32(6):657-65. doi: 10.1002/ijc.2910320603.
With the aim of potentiating the anti-tumour effect of interferon in metastatic malignant melanoma by concomitant inhibition of suppressor T cells, oral cimetidine (histamine-2 receptor antagonist) medication was added to interferon (HuIFN-alpha(Le] therapy in a series of 20 patients. While no objective tumour responses were recorded with interferon treatment alone administered intramuscularly or intratumorally, six patients had objective tumour regressions on subsequent combined therapy. Five out of eight patients with metastases confined to skin and subcutaneous tissue had complete tumour regressions while one patient with skin and lung metastases achieved an extensive partial regression of the skin tumour and a complete roentgenological regression of the lung metastasis. Three additional patients attained a stable disease status for prolonged periods of time. Histopathological examinations confirmed disappearance and/or degeneration of melanoma cells and demonstrated a marked lymphocyte infiltration in tumour sites of the patients with objective tumour regression.
为了通过同时抑制抑制性T细胞来增强干扰素对转移性恶性黑色素瘤的抗肿瘤作用，在20例患者的干扰素（HuIFN-α[Le]）治疗中加入了口服西咪替丁（组胺-2受体拮抗剂）。单独肌肉注射或瘤内注射干扰素治疗时未记录到客观的肿瘤反应，但在随后的联合治疗中有6例患者出现了客观的肿瘤消退。8例转移局限于皮肤和皮下组织的患者中有5例肿瘤完全消退，1例皮肤和肺转移患者皮肤肿瘤广泛部分消退，肺部转移灶放射学完全消退。另外3例患者病情长期稳定。组织病理学检查证实黑色素瘤细胞消失和/或退变，并显示在客观肿瘤消退患者的肿瘤部位有明显的淋巴细胞浸润。
