Richtig E, Hoff M, Rehak P, Kapp K, Hofmann-Wellenhof R, Zalaudek I, Poschauko J, Uggowitzer M, Kohek P, Smolle J
Department of Dermatology, University of Graz, Auenbruggerplatz 8, 8036 Graz, Austria.
J Dtsch Dermatol Ges. 2003 Aug;1(8):635-42. doi: 10.1046/j.1610-0387.2003.03719.x.
Response rates of cutaneous-subcutaneous or lymph node metastases of melanoma to systemic chemotherapy are rather low. We report our clinical experience with superficial and deep regional hyperthermia in combination with radiotherapy and/or chemotherapy with carboplatin.
PATIENTS/METHODS: We treated 15 patients with metastatic melanoma (6 men, 9 women; age 39-84 years, mean age 60 years) by using superficial or deep regional hyperthermia produced by electromagnetic energy. Superficial hyperthermia was delivered to skin or lymph node metastases in combination with radiochemotherapy in 12 patients, while deep regional hyperthermia was administered with an annular array applicator to lymph node metastases either in combination with radiochemotherapy (1 patient) or with carboplatin alone (2 patients). The clinical response was assessed by clinical evaluation and/or computer tomography and/or ultrasonography at monthly intervals.
Both superficial and deep regional hyperthermia was well tolerated. We observed 5 complete local remissions (34%), 6 partial local remissions (40%) and 2 patients with stable disease (13%). The best results were obtained in cutaneous or retroperitoneal metastases.
Local response can be achieved in inoperable metastatic melanoma using superficial or deep regional hyperthermia in combination with radiochemotherapy or chemotherapy.
黑色素瘤皮肤-皮下或淋巴结转移对全身化疗的缓解率相当低。我们报告了我们使用浅表和深部区域热疗联合放疗和/或卡铂化疗的临床经验。
患者/方法：我们使用电磁能量产生的浅表或深部区域热疗治疗了15例转移性黑色素瘤患者（6例男性，9例女性；年龄39 - 84岁，平均年龄60岁）。12例患者的皮肤或淋巴结转移接受了浅表热疗联合放化疗，而深部区域热疗通过环形阵列施源器用于淋巴结转移，其中1例患者联合放化疗，2例患者仅联合卡铂。每月通过临床评估和/或计算机断层扫描和/或超声检查评估临床反应。
浅表和深部区域热疗耐受性均良好。我们观察到5例完全局部缓解（34%），6例部分局部缓解（40%），2例病情稳定（13%）。在皮肤或腹膜后转移中取得了最佳结果。
对于无法手术的转移性黑色素瘤，使用浅表或深部区域热疗联合放化疗或化疗可实现局部缓解。
