Lundegårdh G, Ekbom A, McLaughlin J K, Nyrén O
Cancer Epidemiology Unit, University Hospital, Uppsala, Sweden.
Gut. 1994 Jul;35(7):946-9. doi: 10.1136/gut.35.7.946.
The risk of gastric cancer after vagotomy for benign gastric and duodenal disease was examined in a population based cohort of 7198 patients operated on during 1971-79 and followed up until 1988. After exclusion of the first year of follow up there were 34 cases of gastric cancer compared with 25.6 expected (standardised incidence ratio (SIR) = 1.33; 95% confidence intervals (CI) 0.92 to 1.86). Separate analyses by duration of follow up, sex, age at operation, underlying diagnosis, and operative procedures did not show any significant increased or decreased risk of gastric cancer in any of the subgroups. In conclusion, decreased gastric acid secretion after vagotomy does not increase the risk of gastric cancer in the first 10 years after operation or in the subgroup followed up for 10-18 years. A longer follow-up is needed before an excess risk can be excluded.
对1971年至1979年期间接受手术的7198例患者进行基于人群的队列研究，以检查因良性胃和十二指肠疾病行迷走神经切断术后患胃癌的风险，并随访至1988年。排除随访的第一年之后，有34例胃癌病例，而预期为25.6例（标准化发病率比（SIR）=1.33；95%置信区间（CI）0.92至1.86）。按随访时间、性别、手术时年龄、基础诊断和手术方式进行的单独分析未显示任何亚组中患胃癌的风险有显著增加或降低。总之，迷走神经切断术后胃酸分泌减少不会增加术后头10年或随访10至18年亚组中患胃癌的风险。在排除额外风险之前，需要更长时间的随访。
