Keller F, Schoole J
Int J Clin Pharmacol Ther Toxicol. 1983 Nov;21(11):563-8.
The value of pharmacokinetic parameters is confirmed by clinical impacts. Drug dosage recommendations are usually derived from the one-compartment model and linear first-order kinetics. These are described by the parameters bioavailability, volume of distribution, and elimination half-life. Thus, elimination half-life and volume of distribution are the most important clinical pharmacokinetic parameters and the one-compartment model is the most universal pharmacokinetic concept. Drug clearance provides no further information. To evaluate drug clearance, the AUC must be extrapolated. This requires the assumption of a compartment model. The intrinsic hepatic clearance cannot be equated with hepatic metabolism capacity. Therefore, drug clearance does not appear to be a superior pharmacokinetic parameter.
药代动力学参数的值由临床影响来证实。药物剂量推荐通常源自单室模型和线性一级动力学。这些由生物利用度、分布容积和消除半衰期等参数来描述。因此，消除半衰期和分布容积是最重要的临床药代动力学参数，且单室模型是最通用的药代动力学概念。药物清除率并未提供更多信息。为评估药物清除率，必须外推曲线下面积（AUC）。这需要假设一个房室模型。肝脏固有清除率不能等同于肝脏代谢能力。因此，药物清除率似乎并非一个更优越的药代动力学参数。
