Weiss M, Sziegoleit W, Förster W
Int J Clin Pharmacol Biopharm. 1977 Dec;15(12):572-5.
By employing the theory of biological similarity, equations concerning the dependence of the clearance on the body weight are being presented for different elimination processes. Changes in the biological half-life depending on the body weight are demonstrated by way of the one and two compartment model. The discussion of the results based on our own data as well as those derived from literature shows that it is very ofter possible to estimate the weight-depending differences between half-lives of various species by simple empirical formulas.
通过运用生物相似性理论，针对不同的消除过程，给出了关于清除率与体重依赖性的方程。通过一室和二室模型展示了生物半衰期随体重的变化情况。基于我们自己的数据以及从文献中获得的数据对结果进行的讨论表明，通过简单的经验公式常常能够估算出不同物种半衰期之间与体重相关的差异。
