钙拮抗剂对大鼠被动皮肤过敏反应的影响。

Effects of calcium-antagonists on passive cutaneous anaphylaxis in the rat.

作者信息

Hertz F, Ranson M, DeFeudis F V, Deghenghi R

出版信息

Int J Immunopharmacol. 1983;5(5):427-9. doi: 10.1016/0192-0561(83)90018-8.

Abstract

The actions of four Ca2+-antagonists (nifedipine, verapamil, diltiazem and D 600) were compared with those of four substances that are used clinically in treating asthma (theophylline, isoproterenol, disodium cromoglycate and clemastine), using the passive cutaneous anaphylaxis (PCA) reaction in the rat. Nifedipine, verapamil and diltiazem produced a partial, but dose-related inhibition of the PCA reaction. A slight, but significant inhibitory effect was also observed with D 600. Isoproterenol, theophylline and disodium cromoglycate also produced dose-related inhibition of the PCA reaction, their maximum effects being greater than those of the Ca2+-antagonists. As the histamine H1-antagonist clemastine was about as active as nifedipine, verapamil or diltiazem in inhibiting the PCA reaction, it seems possible that certain Ca2+-antagonists might be of value in treating allergic disorders in man.

摘要

利用大鼠被动皮肤过敏反应（PCA），比较了四种钙拮抗剂（硝苯地平、维拉帕米、地尔硫䓬和D 600）与四种临床用于治疗哮喘的物质（茶碱、异丙肾上腺素、色甘酸钠和氯马斯汀）的作用。硝苯地平、维拉帕米和地尔硫䓬对PCA反应产生了部分但与剂量相关的抑制作用。D 600也观察到了轻微但显著的抑制作用。异丙肾上腺素、茶碱和色甘酸钠也对PCA反应产生了与剂量相关的抑制作用，它们的最大作用大于钙拮抗剂。由于组胺H1拮抗剂氯马斯汀在抑制PCA反应方面与硝苯地平、维拉帕米或地尔硫䓬活性相当，因此某些钙拮抗剂似乎可能对治疗人类过敏性疾病有价值。