McPhillips D M, Armer T A, Owen D R
J Biomed Mater Res. 1983 Nov;17(6):993-1002. doi: 10.1002/jbm.820170609.
A series of porous polymeric sorbents and activated carbon were used to remove diisopropyl methylphosphonate (DIMP) from human plasma and normal saline. The sorptive capacities of the commercially available sorbents Amberlite XAD-4, XAD-2, XN1010, and XE348, and Calgon 400 were determined. Butyl- and palmityl-grafted XAD-4 were prepared with graft efficiencies of 32 and 6%, respectively, and tested for sorptive capacities. DIMP removal efficiencies were compared to dialysis with a 1.8 m2 Cordis-Dow hollow fiber artificial kidneY (HFAK). Butyl-grafted XAD-4 and active carbon outperformed the other sorbents in removing DIMP from both saline and plasma. An order of magnitude reduction in removal ability was noted for all the adsorbents when the mobile media was plasma. Pronounced plasma precipitation was elicited by activated carbon, an effect not observed with any of the polymeric resins tested. The removal efficiencies on a 18.0 g basis of XAD-4, butyl-grafted XAD-4, and active carbon were comparable to that of the HFAK used in this study. These sorbents, however, possess a macroscopic surface area of approximately 0.1 m2, an order of magnitude lower than that of the HFAK. This reduction in contact area is believed to reduce substantially the possibility of undesirable molecular and cellular effects.
使用一系列多孔聚合物吸附剂和活性炭从人血浆和生理盐水中去除甲基膦酸二异丙酯（DIMP）。测定了市售吸附剂Amberlite XAD - 4、XAD - 2、XN1010、XE348和Calgon 400的吸附容量。制备了丁基和棕榈酰基接枝的XAD - 4，接枝效率分别为32%和6%，并测试了其吸附容量。将DIMP去除效率与使用1.8平方米Cordis - Dow中空纤维人工肾（HFAK）进行透析的效率进行了比较。丁基接枝的XAD - 4和活性炭在从盐水和血浆中去除DIMP方面优于其他吸附剂。当流动介质为血浆时，所有吸附剂的去除能力均降低了一个数量级。活性炭引发了明显的血浆沉淀，在所测试的任何一种聚合物树脂中均未观察到这种现象。以18.0克为基础，XAD - 4、丁基接枝的XAD - 4和活性炭的去除效率与本研究中使用的HFAK相当。然而，这些吸附剂的宏观表面积约为0.1平方米，比HFAK低一个数量级。据信这种接触面积的减小会大幅降低不良分子和细胞效应的可能性。
