Schmer G, Teng L N, Cole J J, Vizzo J E, Francisco M M, Scribner B H
Trans Am Soc Artif Intern Organs. 1976;22:654-63.
A total of 33 totally heparin-grafted dialysis systems using HFAK Cordis Dow Models 3 and 4 have been compared to a total of 23 nongrafted systems. The comparison of deltap, flow rate, FBVL and macroscopic inspection showed highly significant differences in favor of the heparin-grafted systems. The antithrombogenic performance of the totally heparin-grafted systems is mainly due to a small leakage of heparin during the experiments. A minimum of 1.35 X 10(-8) Gm/cm2/min of heparin is sufficient to prevent clotting at the blood-polymer interface.
总共33个使用HFAK Cordis Dow型号3和4的全肝素化透析系统与23个未肝素化系统进行了比较。对跨膜压差、流速、纤维蛋白原消耗率（FBVL）和宏观检查的比较显示，全肝素化系统具有显著优势。全肝素化系统的抗血栓形成性能主要归因于实验过程中肝素的少量渗漏。最低1.35×10⁻⁸克/平方厘米/分钟的肝素足以防止血液与聚合物界面处形成凝血。
