亚硝基甲基烷基胺诱导大鼠食管肿瘤
Induction of tumors of the esophagus in rats by nitrosomethylalkylamines.
作者信息
Lijinsky W, Reuber M D, Singer G M
出版信息
J Cancer Res Clin Oncol. 1983;106(3):171-5. doi: 10.1007/BF00402603.
The carcinogenic effectiveness of nitrosomethyl-n-butylamine,-n-hexylamine and -n-heptylamine was compared by administration to F344 rats at various concentrations in drinking water and by gavage in oil. Nitrosomethylbutylamine induced only tumors of the upper gastrointestinal tract, and was very toxic. Nitrosomethylhexylamine was less toxic and induced tumors of the liver and lung, as well as those the upper GI tract, when given by gavage, but only tumors of the GI tract when given in drinking water. In contrast, nitrosomethylheptylamine induced tumors of the liver and lung when given in drinking water or by gavage, but there were tumors of the esophagus only in those rats treated via the drinking water. As measured by the dose needed to produce a given carcinogenic effect, nitrosomethylheptylamine was a weaker carcinogen than the other two nitrosamines, but was not inactive as has been reported previously.
通过在饮用水中以不同浓度给予F344大鼠以及通过油剂灌胃的方式，比较了亚硝基甲基正丁胺、亚硝基甲基正己胺和亚硝基甲基正庚胺的致癌效力。亚硝基甲基丁胺仅诱发上消化道肿瘤，且毒性很强。亚硝基甲基己胺毒性较小，通过灌胃给药时可诱发肝脏和肺部肿瘤以及上消化道肿瘤，但通过饮用水给药时仅诱发胃肠道肿瘤。相比之下，亚硝基甲基正庚胺通过饮用水或灌胃给药时均可诱发肝脏和肺部肿瘤，但仅在通过饮用水处理的大鼠中出现食管肿瘤。以产生特定致癌效应所需的剂量衡量，亚硝基甲基正庚胺的致癌性比其他两种亚硝胺弱，但并不像之前报道的那样无致癌活性。
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