Ege G N, Nold J B, Eng R R, Durakovic A, Conklin J J
J Reticuloendothel Soc. 1983 Dec;34(6):449-62.
Effects of a metastatic and nonmetastatic tumor on radiocolloid localization in regional lymph nodes in the rat were studied in order to examine further the hypothesis that suppression of radiocolloid uptake results from inhibition of macrophage phagocytic function by tumor products. On the basis of data obtained in the present model using homogenates of autologous spleen and two weakly immunogenic tumors introduced into the foot pad of rats, it is proposed that decreased radiocolloid uptake induced by a regional neoplasm may result from proliferation of nonphagocytic cellular elements within the regional lymph nodes and alterations in the cell population at the site of radiocolloid injection, which impede the transport of interstitially administered radiocolloid and its access to phagocytic macrophages, within primary and secondary regional lymph nodes. In its inception, therefore, suppression of radiocolloid uptake is not unique to neoplasia and may not directly reflect altered phagocytosis.
为了进一步检验肿瘤产物抑制巨噬细胞吞噬功能导致放射性胶体摄取受抑制这一假说，研究了转移性和非转移性肿瘤对大鼠局部淋巴结放射性胶体定位的影响。基于使用自体脾脏匀浆和两种弱免疫原性肿瘤接种于大鼠足垫的本模型所获得的数据，提出局部肿瘤诱导的放射性胶体摄取减少可能是由于局部淋巴结内非吞噬性细胞成分的增殖以及放射性胶体注射部位细胞群的改变，这阻碍了间质注射的放射性胶体在初级和次级局部淋巴结内的运输及其与吞噬性巨噬细胞的接触。因此，在其初始阶段，放射性胶体摄取的抑制并非肿瘤所特有，可能并不直接反映吞噬作用的改变。
