Zaretskaya R B, Trutneva K V, Ostrovskaya R U, Markin V A, Zueva M V, Suprun A V
Metab Pediatr Syst Ophthalmol. 1983;7(3):159-67.
This paper presents the results of an electrophysiologic and histochemical study on the effect of sodium hydroxybutyrate applied perorally as 5% syrup for 20 days on the rabbit retina. It was found with statistical significance that in response to the drug the amplitudes of "a" and "b" waves of the electroretinogram increased considerably and the activation of some dehydrogenases, glucose-6-phosphatedehydrogenase and lactatedehydrogenase in particular took place; this was most pronounced in the ganglion and in the inner nuclear layers of the retina. The results of the study show that a prolonged peroral application of 5% sodium hydroxybutyrate syrup might be an expeditious way to activate energy processes in the retina.
本文介绍了一项电生理和组织化学研究的结果，该研究旨在探讨以5%糖浆形式经口给予羟基丁酸钠20天对兔视网膜的影响。具有统计学意义的是，发现药物作用后视网膜电图的“a”波和“b”波振幅显著增加，同时一些脱氢酶，尤其是葡萄糖-6-磷酸脱氢酶和乳酸脱氢酶被激活；这在视网膜的神经节层和内核层最为明显。研究结果表明，长期经口应用5%羟基丁酸钠糖浆可能是激活视网膜能量代谢过程的一种快速方法。
