Pascual M R, Macías A, Moreno L, Lage A
Neoplasma. 1983;30(5):589-92.
Prognosis in breast cancer is one of the most important subjects currently studied because of the heterogeneity of the disease even inside the same clinical stage. Estrogen receptor determination in human breast cancer has been recognized as a prognostic factor since it is related to the long-term survival and disease-free interval. In a series of papers concerning prognosis in breast cancer this the third one which includes estrogen receptor determination in the multivariate analysis, because of the limitations of the clinical factor to conform stratification groups. We have analyzed the short term probability of relapse in a group of 136 patients treated for breast cancer. Multivariate stratification analysis was performed with the aid of Bintree computer program, which produces binary splits of the population according to the criterion of maximal reduction of variance and generates a binary stratification tree. Lymph node involvement is the most important prognostic factor in the probability of relapse. Patients without nodal involvement lacking estradiol receptor had 25% of relapse. It is therefore evident that estradiol receptor is a factor of prognostic value even inside node negative patients.
由于乳腺癌即使在同一临床分期内也具有异质性，因此乳腺癌的预后是目前研究的最重要课题之一。自雌激素受体测定与长期生存和无病间期相关以来，其已被公认为人类乳腺癌的一个预后因素。在一系列关于乳腺癌预后的论文中，这是第三篇在多变量分析中纳入雌激素受体测定的论文，原因是临床因素在形成分层组方面存在局限性。我们分析了一组接受乳腺癌治疗的136例患者的短期复发概率。借助Bintree计算机程序进行多变量分层分析，该程序根据最大方差减少标准对人群进行二元分割，并生成二元分层树。淋巴结受累是复发概率中最重要的预后因素。无淋巴结受累且缺乏雌二醇受体的患者复发率为25%。因此，很明显，即使在淋巴结阴性的患者中，雌二醇受体也是一个具有预后价值的因素。
